消化道出血内镜治疗后降钙素原和C反应蛋白测定及临床意义.docVIP

消化道出血内镜治疗后降钙素原和C反应蛋白测定及临床意义 　　[摘要] 目的 探讨消化道出血内镜治疗后降钙素原（PCT）和C反应蛋白（CRP）的测定对预防感染及应用抗生素的意义。 方法 选取2015年9月～2016年8月我院消化内科收治的消化道出血患者128例，将患者随机分为两组，每组64例。研究组患者接受内镜下治疗并在治疗后使用抗生素预防感染，对照?M仅接受内镜治疗。观察两组患者在内镜治疗前1天、治疗后第1天、第7天的PCT与CRP水平，并记录患者的不良反应发生情况和治疗效果。 结果 两组患者治疗前PCT与CRP水平接近（P0.05），治疗后研究组的PCT和CRP水平分别为（0.97±0.23）ng/mL、（7.24±2.48）ng/mL，均明显低于对照组（P0.05）。研究组不良反应发生率少于对照组（P0.05）；研究组在治疗效果方面显著优于对照组（P0.05）。 结论 对消化道出血患者采用内镜治疗后使用抗生素效果显著，有助于患者的康复。 　　[关键词] 消化道出血；内镜治疗；降钙素原；C反应蛋白 　　[中图分类号] R57 [文献标识码] A [文章编号] 1673-9701（2017）02-0016-03 　　Determination and clinical significance of procalcitonin and C reactive protein after endoscopic treatment of gastrointestinal hemorrhage 　　DU Aiping ZHAI Yajuan ZHANG Liwei ZHANG Wei ZHENG Xin YANG Lu YU Jing WANG Wenbin 　　Department of Gastroenterology， the Second Affiliated Hospital of Qiqihar Medical School， Qigihar 161000， China 　　[Abstract] Objective To investigate the significance of procalcitonin and C reactive protein after gastrointestinal endoscopy in the prevention of infection and the use of antibiotics. Methods A total of 128 patients with digestive tract hemorrhage admitted in our hospital from September 2015 to August 2016 were randomly divided into two groups with 64 patients in each group. The patients in the study group were treated by endoscopy and treated antibiotics to prevent infection， the control group received only endoscopic treatment. The levels of PCT and CRP were recorded at 1 day before and 1 day and 7 days after the endoscopic treatment. The incidence of adverse reactions and the therapeutic effect were recorded. Results PCT and CRP levels in the two groups of patients before treatment were close（P0.05）； after treatment， the levels of PCT and CRP in study group were（0.97±0.23）ng/mL and（7.24±2.48）ng/mL， which were significantly lower than those in the control group（P0.05）； the incidence of adverse reactions in the study group was lower than that in the control group（P0.05）. The therapeutic effect in the study group was si