消癌平注射液联合放化疗在局部中晚期鼻咽癌治疗中疗效观察.docVIP

消癌平注射液联合放化疗在局部中晚期鼻咽癌治疗中疗效观察 　　【摘要】 目的：观察消癌平注射液联合诱导化疗及同步放化疗在局部中晚期鼻咽癌治疗中的疗效观察。方法：选取局部中晚期鼻咽癌患者60例，按随机数字表法分为治疗组（消癌平组联合放化疗组）30例和对照组（单纯放化疗组）30例，两组治疗前均未行过化疗、放疗、免疫治疗及中医中药治疗等。观察治疗结束后两组肿瘤病灶变化情况、皮肤及口腔黏膜反应、骨髓抑制程度和肝肾功能情况。结果：治疗结束12个月后复查，治疗组完全缓解率高于对照组，差异有统计学意义（P0.05）；且骨髓抑制较对照组轻（P0.05），其他毒副评价相当。结论：消癌平注射液联合放化疗治疗中晚期鼻咽癌具有增效、减毒作用，值得进一步研究证实。 　　【关键词】 消癌平注射液； 鼻咽癌； 诱导化疗； 同步放化疗 　　Clinical Observation of Xiaoaiping Combined with Radiation and Chemotherapy in Treatment of Nasopharyngeal Carcinoma （NPC）/XIAO Hong-mei，ZOU Yan，WU Xiao-liang.//Medical Innovation of China，2014，11（28）：051-053 　　【Abstract】 Objective：To observe the outcome of combining Xiaoaiping injection treatment with inducing chemotherapy and concurrent chemoradiotherapy on locally advanced nasopharyngeal cancer.Method：60 patients with nasopharyngeal carcinoma （NPC） were select， the patients were randomly divided into two groups： one group of 30 patients were treated with Xiaoaiping combined with inducing chemotherapy and concurrent chemoradiotherapy （the treatment group）， and the other group of 30 patients was treated solely with inducing chemotherapy and concurrent chemoradiotherapy （the control group）. The two groups before treatment had not been done chemotherapy， radiation therapy， immunotherapy and Chinese medicine treatment， etc. The changes of the tumor after treatment， the reaction of skin and mucous membrane of mouth， bone marrow inhibition degree， liver and kidney function were observed.Result：Checked over 12 mon ths after treatment， complete response rate of the treatment group was higher than the control group， the difference was statistically significant （P0.05）， bone marrow suppression was lighter than the control group（P0.05）， the other side evaluation were fairly.Conclusion：Xiaoaiping unites radiation and chemotherapy can increase the curative effect of locally advanced nasopharyngeal carcinoma， to reduce the adverse reaction. 　　【Key words】 Xiaoaiping injection； Nasopharyngeal carcinoma； Induction chemother