消脂护肝胶囊对NAFLD大鼠瘦素胰岛素抵抗影响.docVIP

消脂护肝胶囊对NAFLD大鼠瘦素胰岛素抵抗影响 　　[摘要] 目的 观察中药消脂护肝胶囊对非酒精性脂肪肝（NAFLD）大鼠的治疗作用，探讨其可能的作用机制。 方法 采用复合因素复制大鼠NAFLD模型，选取健康雄性SD大鼠72只，按体重随机分为6组，每组12只：空白对照组（简称空白组）、模型对照组（模型组）、东宝肝泰对照组（东宝组）、消脂护肝胶囊高剂量组（消高组）、消脂护肝胶囊中剂量组（消中组）、消脂护肝胶囊低剂量组（消低组）。观察各组大鼠的血糖、血清瘦素（LP）、胰岛素，丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）；血清总胆固醇（TC）、三酰甘油（（TG）；肝组织病理学。 结果 与模型组比较，消高组、消中组的LP及胰岛素抵抗（IR）指数均明显下降（P0.01）；与模型组比较，消高组（P0.01）、消中组（P0.05）的肝细胞脂变率明显降低。 结论 消脂护肝胶囊能降低血清LP水平，改善IR状态，对NAFLD有良好的防治作用。 　　[关键词] 非酒精性脂肪肝；瘦素；胰岛素抵抗；消脂护肝胶囊 　　[中图分类号] R575.5 [文献标识码] A [文章编号] 1674-4721（2015）08（b）-0011-04 　　Influence of Xiaozhihugan Capsule on leptin and insulin resistance in NAFLD rats 　　NIE Shan-wen1 ZHAO Wen-xia2▲ SHI Yan-fen3 DONG Jing4 LIU Xiao-yan5 MA Su-ping2 　　1.Endoscopy Center，Traditional Chinese Medicine Hospital of Henan Province，Zhengzhou 450002，China；2.Department of Spleen，Stomach，Liver and Gall，the First Hospital Affiliated to Henan University of Traditional Chinese Medicine，Zhengzhou 450008，China；3.Department of Traditional Chinese Medicine，Jiaozuo People′s Hospital in Henan Province，Jiaozuo，454002，China；4.Department of Liver，Gall，Spleen and Stomach，Zhumadian Hospital of Traditional Chinese Medicine in Henan Province，Zhumadian 463000，China；5.Inheritance Studio of Famous Traditional Chinese Medicine Physician，Kaifeng Hospital of Traditional Chinese Medicine，Kaifeng 410200，China 　　[Abstract] Objective To observe the treatment role of Xiaozhihugan Capsule of Chinese medicine for rats with nonalcoholic fatty liver disease （NAFLD），and to discuss its possible mechanism of action. Methods NAFLD model of rate was copied using composite factor.72 healthy and male rats were divided into 6 groups，and there were 12 rats in each group：blank control group （blank group），model control group （model group），dongbaogantai control group （dongbao group），Xiaozhi Hugan Capsule high dose group （Xiaogao group）， Xiaozhi Hugan Capsule middle dose group （Xiaozhong group）， Xiaozhi Hugan capsule low dose group （Xiaodi group）.Blood sugar，serum leptin （LP），insulin；se