滋肾降糖丸对糖尿病大血管病变患者血清脂联素和血管内皮功能影响.docVIP

滋肾降糖丸对糖尿病大血管病变患者血清脂联素和血管内皮功能影响 　　[摘要] 目的：观察滋阴降糖丸对伴有大血管并发症的2型糖尿病患者血清脂联素和血管内皮功能的影响。方法：将入选的120例2型糖尿病合并高血压患者随机分为治疗组60例，对照组60例，两组均予糖尿病相关健康教育，合理饮食并常规应用西药降糖、降压常规治疗，治疗组加用滋阴降糖丸（由黄芪、党参、生地、熟地、怀牛膝、黄精、三七等组成），每次6 g，每日3次，两组疗程均为2个月，测定两组治疗前后，血清脂联素、vWF，NO的水平。结果：两组治疗后均能使脂联素水平升高，ＮＯ浓度升高，vWF水平降低，治疗组治疗前后有显著性差异，而对照组无显著性差异。结论：滋阴降糖丸能提高血清脂联素水平，改善糖尿病合并高血压患者的血管内皮功能。 　　[关键词] 糖尿病；高血压；滋阴降糖丸；血清脂联素 　　[中图分类号] R587.1[文献标识码]A [文章编号]1673-7210（2008）02（c）-018-03 　　 　　Effects of Jiang tang Bushen Recipe(JBR) on serum adiponectin and endothelial function in patients with type 2 diabetic vascopathy 　　Gao Yun-shan,Li Hui-lin, Zhao Heng-xia 　　(Department of Endorinology, Shenzhen Hospital of Tradictional Chinest Medicine, Shenzhen 518033, China) 　　[Abstract] Objective: To study the effect of Jiang tang Bushen Recipe(JBR) on serum adiponectin and endothelial function in patients with type 2 diabetic vascopathy.Methods:120 type 2 diabetic patients with hypertension were randomized to trial group (60cases) and control group (60 cases), besides, another healthy group (20 cases) was established. Education course, dietary treatment and conventional hypoglycemic agent were given to both groups. And JBR was given additionally to patients in the treated group. 6 g tid, for two months. Before and after the treatment, Levels of serum adiponectin, nitrous oxide(NO) and Von Willebrand’s factor were assayed.Results:In trial group, levels of serum adiponection and NO increased and FWD increased significantly. While vWF decreased as compared with before treatment,all were noted to be of significances(P＜0.05，or P＜0.01). NO significance was found in the control group after treatment as compared with before treatment(P0.05).Conclusion: JBR can enchance serum adiponectin level and improve endothelial function in type 2 diabetic patients with hyperension. 　　[Key words] Diabetes; Hypertension; Jiang tang Bushen Recipe; Serum adiponectin 　　 　　脂联素是新近发现的由脂肪细胞特异性分泌的蛋白质，与胰岛素抵抗、2型糖尿病及心血管疾病密切相关。2型糖尿病合并高血压是糖尿病常见的慢性血管并发症之一。高血压可加