滋肾调周法对反复体外受精―胚胎移植失败者卵巢反应性影响.docVIP

滋肾调周法对反复体外受精―胚胎移植失败者卵巢反应性影响 　　摘要：目的 探讨滋肾调周法对胚胎反复移植失败（RIF）患者卵巢反应性的影响。方法 采用随机数字表，按照1∶1比例将70例RIF患者分为滋肾调周治疗组和空白对照组。滋肾调周治疗组从月经第5日开始服用温肾养血颗粒，第10日改为培育颗粒，连用15 d。空白对照组不用药。3个月为1个疗程。观察患者治疗前后中医证候评分、血清卵泡刺激素（FSH）和黄体生成素（LH）水平、子宫和卵巢体积、窦卵泡计数（AFC）及进入体外受精（IVF）周期后的临床妊娠率。结果 滋肾调周治疗组可提高临床妊娠率，但与空白对照组比较差异无统计学意义（P0.05）。滋肾调周治疗组可显著改善中医证候评分（P0.05）。结论 滋肾调周法可改善RIF患者中医证候及卵巢反应性，提高进入IVF周期后的临床妊娠率。 　　关键词：滋肾调周；反复体外受精-胚胎移植失败；卵巢反应性 　　DOI：10.3969/j.issn.1005-5304.2015.11.005 　　中图分类号：R271.952 文献标识码：A 文章编号：1005-5304（2015）11-0016-05 　　Effects of Ovarian Response on RIF by Treatment of Zishen Tiaozhou YANG Wei， HE Jun-qin， GUO Chun-yu， LI Ma-jian， WANG Yu-wen， GAO Ai-ping， ZHANG Ying， XIN Ming-wei， WU Ying， LIANG Xin-yun， YIN Xiao-dan （Beijing Gynaecology and Obstetrics Hospital， Capital University of Medical Science， Beijing 100006， China） 　　Abstract：Objective To observe the ovarian response of repeated implantation failure （RIF） by the treatment of Zishen Tiaozhou. Methods Totally 70 patients with RIF were randomly divided into treatment group and blank control group averagely through random number table method. Treatment group was given Wenshen Yangxue Granule from the 5th day of the menstrual cycle and Peiyu Granule from the 10th day of the menstrual cycle， for successive 15 days. Three months was a treatment course. TCM syndrome score， FSH and LH in serum， uterine and ovarian volume， antral follicle count （AFC） before and after treatment， and clinical pregnancy rate into the IVF cycle of all patients were observed. Results The treatment group could increase the clinical pregnancy rate but had no statistical difference compared with blank control group （P0.05）. The treatment group could significantly improve the TCM syndrome score （P0.05）. Conclusion The treatment of Zishen Tiaozhou can improve the TCM syndrome score and ovarian response， and increase the clinical pregnancy rate. 　　Key words：Zishen Tiaozhou；repeated implantation failure；ovarian response 　　体外受精-胚胎移植（IVF-ET）技术的诞生，为不孕不育的治疗打开了新的局面。随着