激光治疗尖锐湿疣后外用咪喹莫特乳膏效果研究.docVIP

激光治疗尖锐湿疣后外用咪喹莫特乳膏效果研究 　　【摘要】目的：探讨激光治疗尖锐湿疣后外用咪喹莫特乳膏治疗的效果。方法：选择我院2013年3月至2015年3月治疗的尖锐湿疣患者110例，按照治疗方案分为激光组（50例）和联合治疗组（60例），比较两组患者在治疗后的痊愈率和第4、8、12周的复发率和治疗后不良反应。 结果：联合治疗组治疗后的痊愈率明显高于激光组，而同期的复发率明显低于激光组，两组上述数据比较，差异有统计学意义（P0.05）。12周后联合治疗组的CD3+、CD4+T淋巴细胞百分率及CD4+/CD8+值明显高于激光组，而CD8+T淋巴细胞百分数明显低于激光组，差异有统计学意义（P0.05）。 结论：激光治疗尖锐湿疣后继用5 %咪喹莫特乳膏是一种安全有效的治疗方案。 　　【关键词】激光； 尖锐湿疣；咪喹莫特乳膏 　　Effect of imiquimod cream for external use in condyloma acuminatum after laser surgical therapyLAI Aimin1， XU Xiaorong2， ZHENG Junbin1， HUANG Qizhou1. 1.Department of Dermatology STD， Shantou Chaonan Minsheng Hospital， Shantou 515144， Guangdong， China； 2.Department of Dermatology， The First Hospital Affiliated to Medical College of Shantou University， Shantou 515041， Guangdong， China 　　【Abstract】Objectives： To investigate the effects of imiquimod cream for external use in condyloma acuminatum after laser surgical therapy. Methods： A total of 110 patients with condyloma acuminatum treated in our hospital from March 2013 to March 2015 were enrolled and divided into laser group （50 cases） and combination therapy group （60 cases） according to their therapy method. The cure rates， recurrence rates 4th week， 8th week and 12th week after the treatment， and adverse reactions of two groups were compared. Results： The cure rate of combination therapy group was significantly higher than that of laser group， while the recurrence rates in combination therapy group 4th week， 8th week and 12th week after the treatment were significantly lower than those of laser group （P0.05）. After 12 weeks， CD3+， CD4+T lymphocyte percentage and CD4+/CD8+ of combination therapy group was significantly higher than those of laser group （P0.05）. However， CD8+T lymphocyte percentage of combination therapy group was significantly lower than that of laser group （P0.05）. Conclusion： The application of 5% imiquimod cream in condyloma acuminatum after laser surgical therapy is a safe and effective therapy. 　　【Key words】Laser； Condyloma acum