硒制剂在桥本甲状腺炎伴甲状腺功能减退中应用分析.docVIP

硒制剂在桥本甲状腺炎伴甲状腺功能减退中应用分析 　　[摘要] 目的 分析硒制剂在桥本甲状腺炎伴甲状腺功能减退中的应用效果。 方法 整群选取2014年2月―2015年3月该院收治的桥本甲状腺炎伴甲状腺功能减退患者63例，随机分为两组。其中对照组采用传统治疗即口服甲状腺素，观察组在此基础上给予硒制剂治疗。记录两组患者治疗前后的血清游离三碘甲腺原氨酸、游离甲状腺素、促甲状腺激素、白介素2、白介素4变化。 结果 治疗后观察组血清游离三碘甲腺原氨酸[（4.16±0.24）vs（3.87±0.27）]、游离甲状腺素[（14.42±0.89）vs（12.06±1.23）]、白介素4[（1.14±0.11）vs（0.98±0.15）]高于对照组，促甲状腺激素[（4.83±3.24）vs（10.28±5.16）]、白介素2[（3.86±0.37）vs（4.37±0.34）]均低于对照组，差异有统计学意义（P0.05）。 结论 硒制剂可纠正甲状腺功能减退状态，提高桥本甲状腺炎伴甲状腺功能减退患者的临床效果。 　　[关键词] 硒制剂；桥本甲状腺炎；甲状腺功能减退 　　[中图分类号] R581 [文献标识码] A [文章编号] 1674-0742（2016）02（a）-0150-02 　　Application Analysis of Selenium Preparation in the Hashimotos Thyroiditis with Hypothyrea 　　CHE Wei-juan 　　Endocrine Department， Daqing Fourth Hospital， Daqing， Heilongjiang Province， 163712 China 　　[Abstract] Objective To analyze the application effect of selenium preparation in the hashimotos thyroiditis with hypothyrea. Methods 63 cases of patients with hashimotos thyroiditis with hypothyrea treated in our hospital from February 2014 to March 2015 were randomly divided into two groups， the control group were given traditional treatment namely oral administration of thyroid hormone， the observation group were given selenium preparation treatment on this basis， the changes of serum free triiodothyronine， free thyroxine， hormothyrin， interleukin-2 and interleukin-4 of the two groups before and after treatment were recorded. Results After treatment， the serum free triiodothyronine， free thyroxine and interleukin-4 in the observation group were respectively [（4.16±0.24）vs（3.87±0.27）]， [（14.42±0.89）vs（12.06±1.23）] and [（1.14±0.11）vs（0.98±0.15）]， which were higher than those in the control group， the hormothyrina and interleukin-2 in the observation group were respectively [（4.83±3.24）vs（10.28±5.16）] and [（3.86±0.37）vs（4.37±0.34）]， which were lower than those in the control group， and the differences were statistically significant （P0.05）. Conclusion Selenium preparation can correct hypothyroidism status and improve the clinical e