红藤愈萎养胃汤对胃癌前病变血清胃癌相关抗原MG7胃蛋白酶原表达影响.docVIP

红藤愈萎养胃汤对胃癌前病变血清胃癌相关抗原MG7胃蛋白酶原表达影响 　　 摘 要：目的：研究红藤愈萎养胃汤对慢性萎缩性胃炎（CAG）伴胃癌前病变患者血清胃癌相关抗原MG7（sMG7-Ag）、胃蛋白酶原（sPG）表达的影响。方法：用随机表法将90例患者分为西药组（n=30）、胃复春组(n=30)和红藤愈萎养胃汤组(n=30)，检测治疗前、治疗30天及治疗60天后sMG7-Ag、sPGI和sPGII水平。结果：①治疗前红藤愈萎养胃汤组sMG7-Ag （136.50±54.60）ng/L，sPGI （121.74±26.31）μg/L，sPGII （25.40±5.08）μg/L，sPGI/sPGII （4.80± 0.52）；②治疗30天后红藤愈萎养胃汤组sMG7-Ag （135.47±53.24）ng/L，sPGI （159.55±19.27）μg/L，sPGII （26.63± 4.45）μg/L，sPGI/sPGII （6.05±0.52）；③治疗60天红藤愈萎养胃汤组sMG7-Ag （130.48± 49.01）ng/L，sPGI （188.90±14.17）μg/L，sPGII （29.07±4.41）μg/L，sPGI/sPGII （6.58±0.67）。结论：红藤愈萎养胃汤能提高CAG伴癌前病变患者sPGI、sPGII以及sPGI/sPGII，但尚不能显著降低sMG7-Ag。 　　 关键词：红藤愈萎养胃汤；萎缩性胃炎；胃癌前病变；胃癌相关抗原；胃蛋白酶原 　　中图分类号：R285.5 文献标识码：B 文章编号：1673-7717(2012)01-0070-03 　　Effect of Hongteng Yuwei Yangwei Decoction on Serum Expression of Gastric Cancer- 　　associated Antigen MG7 and Pepsinogen of Gastric Precancerosis 　　MA Wei?ming,CHEN Xiao?teng,KANG Nian?song,CHEN Zhen?hao,CEN Ying?dong,DU Yu?lin,GAO Wang?wang. 　　(Yuyao Traditional Chinese Medicine Hospital,Yuyao 315400，Zhejiang，China) 　　Abstract:Objective:To study effect of Hongteng Yuwei Yangwei decoction on serum expression of gastric cancer-associated antigen MG7(sMG7-Ag) and pepsinogen(sPG) of chronic atrophic gastritis(CAG) with gastric precancerosis.Methods:90 patients were divided into western medicine group(n=30),Weifuchun group(n=30) and Hongteng Yuwei Yangwei group(n=30) by method of random number. sMG7-Ag, sPGI, sPGII and sPGI/sPGII were tested before treatment, and after 30-day and 60-day treatment.Results:①sMG7-Ag of Hongteng Yuwei Yangwei group before treatment was （136.50±54.60）ng/L, sPGI （121.74±26.31）μg/L, sPGII （25.40±5.08）μg/L and sPGI/sPGII （4.80±0.52）. ②sMG7-Ag of Hongteng Yuwei Yangwei group after 30-day treatment was （135.47±53.24）ng/L, sPGI （159.55±19.27）μg/L, sPGII （26.63±4.45）μg/L and sPGI/sPGII （6.05±0.52）.③sMG7-Ag of Hongteng Yuwei Yangwei group after 60-day treatment was （130.48±49.01）ng/L, sPGI （188.90±14.17）μg/L, sPGII （29.07±4.41）μg/L, sPGI/sPGII （6.58±0.67