纳米钛膜种植体骨界面骨整合研究.docVIP

纳米钛膜种植体骨界面骨整合研究 　　[摘要]目的研究纳米材料在种植体骨整合方面的作用。方法以磁控溅射法在纯钛种植体表面制备纳米钛膜，观测其形貌，将其植入动物体内，研究其在动物体内的早期骨整合情况。结果表面形貌分析显示，磁控溅射在片状种植体和柱状种植体上形成的纳米级颗粒尺度相近，片状种植体纳米颗粒分布更均匀。动物试验显示，纳米级颗粒钛膜可增加种植体在种植初期的骨整合、骨小梁数量和骨量。结论在材料表面行纳米粒度钛膜改性，有助于提高材料与骨之间的生物活性。 　　[关键词]钛种植体；磁控溅射；表面改性；纳米结构；动物试验 　　[中图分类号]R 783.1[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.03.009 　　The osseointegration research of the interface between bone and implant coating by nano-scale titanium thin filmLiu Yuanyuan1, Li Guo1, Ren Jiayin1, Zhao Shuping1, Nie Jing2, Wang Hu1.（1. Dept. of Radiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; 2. Dept. of Implantation, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China） 　　[Abstract]ObjectiveThe aim of this article is to study on the nano-scale materials in the role of implant os－seointegration. MethodsIn this study, nano-scale titanium films were prepared by direct magnetron sputtering on titanium implants. Then the prepared implants coating with the nano-scale thin film are implanted in the bones of animals. The study of the early integration of the bone will be done between the experimented and control groups. ResultsAnalyzed superficial configuration by magnetron sputtering, it showed that nano-scale granular diaphragm formed and it was homogeneous and compact. Dimension of nano-scale granular on lamellar implants was similar with that on columnar implants. However, nano-scale granular was more homogeneous in lamellar ones. The result of animal experiment showed that initial osseointegration increased after implant surgery utilized implants coating by nano-scale titanium thin film. ConclusionSerial animal experimentation manifested that bioactive can be improved after nano-scale titanium thin film formed on the surface of materials. 　　[Key words]titanium implant；magnetron sputtering；surface modification；nanostructure；animal experimen－tation 　　随着材料学的不断发展，种植修复已成为修复牙列缺失十分重要的方法。种植体的成功在于种植体材料与人体骨组织之间的相互作用，即形成早期的骨结合。为了提高