脑心通胶囊联合低分子肝素钙对急性冠脉综合征患者血清hs―CRPIL―6及血脂影响.docVIP

脑心通胶囊联合低分子肝素钙对急性冠脉综合征患者血清hs―CRPIL―6及血脂影响 　　[摘要] 目的 评价脑心通胶囊联合低分子肝素钙对急性冠脉综合征患者血清hs-CRP、IL-6及血脂的影响。方法88例老年急性冠脉综合征患者，随机分为对照组和观察组，每组44例。对照组采用常规治疗；观察组在对照组常规治疗方式基础上，加用低分子肝素钙注射液及脑心通胶囊治疗。 结果 经过治疗，观察组患者LVEF、CO、E/A的改善情况显著优于对照组，差异有统计学意义（P0.01或0.05）。治疗后观察组心绞痛发作次数及持续时间分别为（1.9±0.5）次、（1.6±0.4）min，少于对照组的（4.5±1.3）次、（4.8±1.2）min，差异有统计学意义（P0.01）。治疗后观察组患者CHOL、TG及LDL-C分别为（5.13±0.53）mmol/L、（2.34±0.55）mmol/L、（2.15±0.65）mmol/L，低于对照组的（6.36±0.58）mmol/L、（3.57±0.88）mmol/L、（3.16±0.33）mmol/L，差异有统计学意义（P0.01）。治疗后观察组患者血清IL-6、hs-CRP分别为（6.64±2.1）ng/L、（3.3±1.1）mg/L，低于对照组的（8.25±2.2）ng/L、（4.2±1.3）mg/L，差异有统计学意义（P0.01或P0.05）。结论 脑心通胶囊联合低分子肝素钙治疗急性冠脉综合征疗效显著，并能改善患者血清hs-CRP和IL-6及血脂水平。 　　[关键词] 脑心通胶囊；低分子肝素钙；急性冠脉综合征；高敏C反应蛋白；白细胞介素6；血脂 　　[中图分类号] R542.2+2 [文献标识码] A [文章编号] 1673-9701（2014）17-0008-04 　　Naoxintong capsule in combination with nadroparin calcium’s effect on serum hs-CRP，IL-6 and lipids of patients with acute coronary syndrome DU Xiaoma CAI Jianli SHEN Xin 　　Cardiovascular Department，Jinhua City Hospital of Traditional Chinese Medicine in Zhejiang Province，Jinhua 321017， China 　　[Abstract] Objective To study the effect of naoxintong capsule combination nadroparin calcium on serum hs-CRP，IL-6 and lipids of patients with acute coronary syndrome. Methods A total of 88 cases of elder patients with acute coronary syndrome，were randomly divided into control group and observation group， each of 44 patients. Control group patiewts were given conventional therapy. Observation group were added nadroparin calcium injection and naoxintong capsule treatment on the basis of control group’s conventional therapy. Results After treatment， the improvement of LVEF， CO，E/A in observation group were obviously better than control group， the difference had statistic significance（P 　　[Key words] Naoxintong capsule；Nadroparin calcium；Acute coronary syndrome；High-sensitivity C-reactive protein；Interleukin-6； Blood lipid 　　急性冠脉综合征在临床医学中属于较为常见的疾病之一[1]，是一组由急性心肌缺血引起的临床综合征，有研究认为[2]急性冠脉综合征发病的主要原因是由于动脉粥样硬化不稳定斑块的破裂。急性冠脉综合征在临床上有很大的危