舒芬太尼在术后ICU患者镇静镇痛中应用研究.docVIP

舒芬太尼在术后ICU患者镇静镇痛中应用研究 　　[摘要] 目的 探讨舒芬太尼在术后ICU患者镇静镇痛中的临床有效性和安全性。 方法 选择术后ICU患者60例，随机分为对照组和观察组，对照组患者采用芬太尼注射液镇静镇痛，观察组使用舒芬太尼注射液镇静镇痛。比较观察两组患者治疗前及治疗后30 min、60 min、6 h、12 h、24 h、48 h的呼吸频率、脉搏血氧饱和度（SpO2）、氧合指数（PaO2/FiO2）。 结果 两组患者在用药期间至观察结束呼吸频率差异无统计学意义（P0.05），但观察组在镇痛24 h、48 h PaO2/FiO2、SpO2明显高于对照组，差异有统计学意义（P0.05），观察组不良反应发生率明显低于对照组。 结论 舒芬太尼用于术后ICU患者镇静镇痛有效性及安全性较高。 　　[关键词] 舒芬太尼；ICU患者；镇静镇痛 　　[中图分类号] R971+.2 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0176-02 　　Clinical reserch of sufentanil in sedatives and analgesics of the postoperative ICU patients 　　MA Dong-pu LI Bao-lin LI Cheng-jian YANG Cai-fu 　　Department of Intensive Care Unit， Zhengzhou Central Hospital Affiliated to Zhengzhou University， Zhengzhou 450007， China 　　[Abstract] Objective To explore clinical effect and safety of sufentanil in sedatives and analgesics of the postoperative ICU patients. Methods 60 postoperative ICU patients were randomly divided into two groups. The patients in the control group were intravenously treated with fentanyl，while patients in the observation group were intravenously given sufentanil. Then the respiratory frequency， pulse oxygen saturation （SpO2）and oxygenation index（PaO2/FiO2） were compared between the two groups before and 30 minutes， 60 minutes， 6 h， 12 h， 24 h and 48 h after treatment. Results The respiratory frequency shows no insignificant difference between the two groups before and after treatment （P0.05）. There were significant differences in SpO2 and PaO2/FiO2 between the two groups at 24， 48 h after treatment（P0.05）. The clinical adverse drug reaction rate in the observation group was lower than that in control group. Conclusion The sufentanil has better clinical effect and high safety in the sedatives and analgesics of postoperative ICU patients. 　　[Key words] Sufentanil； ICU patients； Sedatives and analgesics 　　镇静镇痛对于术后ICU危重患者有重要意义，可调节或减轻应激反应，减少肺部并发症，促进患者及早活动，预防深静脉血栓形成等，已成为术后ICU患者治疗的重要组成部分。但是由于重症患者多存在呼吸、循环等系统功能异常，导致镇静镇痛药物选择受到限制。舒芬太尼（sufentanil，SF）是临床效果较好的镇痛药物，但随着剂量的增加，