传染病诊治实验室侵袭性真菌感染流行趋势与特征.ppt

CID　2017， DOI: 10.1093/cid/ciw691 CID　2017， DOI: 10.1093/cid/ciw691 WGS analysis genetic relationship 念珠菌耐药机制 念珠菌对唑类药物耐药的危险因素 原发性耐药菌株感染 唑类药物使用 抗厌氧菌药物 肿瘤患者、粒细胞减少 CVC 继发耐药发生 粒细胞减少 慢性肾功能衰竭 器官移植 之前用唑类药物3ds 病区念珠菌对氟康唑耐药15% Mycoses, 2016, 59, 198–219 IFI流行状况 侵袭性念珠菌病流行特点 侵袭性曲霉病流行特点 侵袭性真菌感染流行趋势和特征 Invasive aspergillosis (IA) IA is among the most serious IFIs in immuno-compromised hosts Data from China patients are generally limited Classical risk factors include Underlying disease of the host Co-morbidities Medications Environment or nosocomial risk exposure, and Neutropenia, chemotherapy, and cor