胎盘多肽注射液对股骨粗隆间骨折愈合程度改善作用.docVIP

胎盘多肽注射液对股骨粗隆间骨折愈合程度改善作用 　　摘 要 目的：探讨胎盘多肽注射液对股骨粗隆间骨折（IFF）愈合程度的改善作用。方法：选取IFF手术患者113例，采用随机数字表法将患者分为对照组（n=56，术后采用常规抗感染药物治疗）和观察组（n=57，在对照组基础上采用胎盘多肽注射液治疗），采用ELISA方法测定血清血小板衍生生长因子（PDGF）和人胰岛素生长因子-1（IGF-1）水平，比较两组骨折愈合时间、住院时间、术后感染、髋关节功能Harris评分和血清PDGF、IGF-1水平的差异。结果：观察组骨折愈合时间和住院时间及术后感染率均明显低于对照组（P0.05），治疗后，全部患者上述指标均明显高于治疗前（P0.05），其中观察组上述指标明显高于对照组（P0.05）。结论：胎盘多肽注射液可能通过增加血清PDGF、IGF-1水平显著改善IFF愈合程度，降低骨折愈合时间和住院时间，改善髋关节功能和降低术后感染风险。 　　关键词 胎盘多肽注射液 股骨粗隆间骨折 愈合程度 　　中图分类号：R979.5； R683.42 文献标识码：A 文章编号：1006-1533（2015）19-0034-03 　　Effect of placental polypeptide injection on healing degree of intertrochanter fracture of femur* 　　HE Wei**， LIU Ning， ZENG Congwen， RAO Yan 　　（The People’s Hospital of Ganzhou City， Ganzhou 341000， China） 　　ABSTRACT Objective： To investigate the effect of placental polypeptide injection on healing degree of intertrochanter fracture of femur （IFF）. Methods： One hundred and thirteen cases of patients received IFF operation were randomly divided into a control group （n=56， given postoperative conventional anti-infection therapy） and an observation group （n=57， given placenta polypeptide injection on the base of control group）. The levels of serum platelet derived growth factor （PDGF） and insulin-like growth factor-1 （IGF-1） were detected by an ELISA method. The times for fracture healing and hospitalization， postoperative infection， Harris hip score and the levels of serum PDGF and IGF-1 were compared between two groups. Results： The times for fracture healing and hospitalization and the infection rate of postoperation were significantly lower in the observation group than in the control group （P0.05）. The indicators above mentioned were significantly higher after treatment than before （P0.05） and in the observation group than in the control group （P0.05）. Conclusion： Placenta polypeptide injection can improve femoral intertrochanteric fracture healing degree and the function of hip joint and reduce the times for fracture healing and hospitalization and infectio