苏黄止咳胶囊对咳嗽变异性哮喘患者疗效及免疫因子影响.docVIP

苏黄止咳胶囊对咳嗽变异性哮喘患者疗效及免疫因子影响 　　【摘要】 目的：探讨苏黄止咳胶囊对咳嗽变异性哮喘患者的疗效及免疫因子的影响。方法：选取2010年10月-2014年10月在本院进行治疗的102例咳嗽变异性哮喘患者作为研究对象，按照随机数字表法将其分为观察组和对照组，每组51例。对照组采用常规治疗，观察组在常规治疗的基础上加用苏黄止咳胶囊，共治疗4周。治疗前后测定第一秒用力呼气容积（FEV1）、用力吸气肺活量（FVC）、最大呼气流量（PEF）和血清白细胞介素-4（IL-4）、干扰素-γ（IFN-γ）、白细胞介素-17（IL-17），并对两组患者的临床疗效进行对比。结果：经治疗后，观察组的总有效率96.1%明显高于对照组的82.4%，比较差异有统计学意义（ 字2=4.9930，P=0.0255）。两组治疗后FEV1、FVC、PEF均明显高于治疗前（P0.05）；两组治疗后血清IL-4、IL-17均明显降低，且与对照组治疗后比较，观察组治疗后降低更显著（P0.05）；两组治疗后血清IFN-γ均明显升高，并且与对照组治疗后比较，观察组治疗后升高更显著（P0.05）。结论：咳嗽变异性哮喘患者加用苏黄止咳胶囊不仅可以明显提高疗效，并且可以改善免疫因子的表达。 　　【关键词】 咳嗽变异性哮喘； 苏黄止咳胶囊； 免疫因子 　　Effect of Suhuangzhike Capsule on Efficacy and Immune Factors of Patients with Cough Variant Asthma/LIU Wei.//Medical Innovation of China，2015，12（26）：059-062 　　【Abstract】 Objective：To investigate the effect of Suhuangzhike Capsule on efficacy and immune factors of patients with cough variant asthma.Method：102 patients with cough variant asthma admitted to our hospital from October 2010 to October 2014 were selected as research objects，they were divided into the observation group and the control group according to the random number table method，51 cases in each group.The control group was treated with conventional treatment，while the observation group was treated with Suhuangzhike Capsule on the basis of the conventional treatment.They were treated for four weeks.The FEV1，FVC，PEF and interleukin-4（IL-4），interferon γ（IFN-γ），interleukin-17（IL-17） were measured before and after treatment.The clinical curative effect between the two groups were compared.Result：After treatment，the total effective rate of the observation group was 96.1%，which was significantly higher than 82.4% of the control group，the difference was statistically significant（ 字2=4.9930，P=0.0255）.The FEV1，FVC，PEF of the two groups after treatment were significantly increased compared with before treatment（P0.05）.The serum IL-4，IL-17 of the two group after treatment were significantly reduced，and compared with the control group after treatment，th