莫西沙星及利福布丁方案治疗复治涂阳肺结核效果.docVIP

莫西沙星及利福布丁方案治疗复治涂阳肺结核效果 　　[摘要] 目的 探讨莫西沙星及利福布丁方案治疗复治涂阳肺结核的效果。 方法 选择2014年1～9月本院收治的肺结核患者66例，根据收治顺序单双号将所有患者分为观察组和对照组，每组33例。所有患者均给予涂阳肺结核标准化疗方案2HREZ/4HR治疗，在此基础上，观察组患者给予莫西沙星及利福布丁方案治疗，两组均连续治疗6个月后对比观察临床疗效、痰菌阴转率和不良反应发生情况。 结果 观察组的总有效率为93.94%，高于对照组的87.88%，但差异无统计学意义（P0.05）；观察组的痰菌阴转率为90.91%，显著高于对照组的66.67%，差异有统计学意义（P0.05）。 结论 与传统涂阳肺结核标准化疗方案比较，联合莫西沙星及利福布丁方案治疗复治涂阳肺结核的效果相当，更能提高痰菌阴转率，且不增加不良反应，具有积极的临床意义。 　　[关键词] 莫西沙星；利福布丁；复治；痰涂片阳性；肺结核 　　[中图分类号] R521.9 [文献标识码] A [文章编号] 1674-4721（2015）08（c）-0051-03 　　[Abstract] Objective To explore the effect of moxifloxacin and rifampicin treating retreated smear-positive pulmonary tuberculosis. Methods 66 patients with pulmonary tuberculosis admitted into our hospital from January to September 2014 were selected and they were divided into observation group and control group according to the even number or odd number of patients′ admission order，and there were 33 patients in each group.All patients were given the treatment of standardized chemotherapy scheme 2HREZ/4HR of smear-positive pulmonary tuberculosis，and on the basis of this treatment，observation group was also given the treatment of moxifloxacin and rifabutin.The clinical curative effect，sputum negative conversion rate and incidence of adverse reaction was compared and observed respectively after 6-month consecutive treatment in two groups. Results The total effective rate in observation group （93.94%） was higher than that of control group （87.88%），but there was no statistical difference （P0.05）；the sputum negative conversion rate in observation group （90.91%） was significantly higher than that of control group （66.67%），and there was a statistical difference （P0.05）. Conclusion Compared with the traditional standardized chemotherapy scheme of smear-positive pulmonary tuberculosis，combining moxifloxacin and rifabutin scheme treating retreated smear-positive pulmonary tuberculosis has equivalent curative effect，is able to improve the sputum negative conversion rate，and does not increase adver