肾小球滤过率对缺血性脑卒中患者脑血管病变及生存状况影响.docVIP

肾小球滤过率对缺血性脑卒中患者脑血管病变及生存状况影响 　　【摘要】 目的：探究肾小球滤过率（glomerular filtration rate，GFR）对缺血性脑卒中患者脑血管病变及生存状况的影响。方法：选取2013年4月-2016年4月本院收治的缺血性脑卒中患者338例为研究对象。根据肾脏病膳食改良试验（modification of diet in renal disease，MDRD）方程计算患者GFR，并通过GFR三分位数将其分为GFR低水平组111例、GFR中水平组114例及GFR高水平组113例。比较三组动脉狭窄严重程度、生存状况（病死率、不良转归率、神经功能恶化率）。结果：GFR低水平组动脉狭窄严重程度均高于GFR中水平组和GFR高水平组，且GFR中水平组高于GFR高水平组，比较差异均有统计学意义（P0.05）；GFR低水平组病死率、神经功能恶化率、不良转归率均显著高于GFR中水平组和GFR高水平组，且GFR中水平组均显著高于GFR高水平组，比较差异均有统计学意义（P0.05）。结论：GFR对缺血性卒中患者脑血管病变及生存状况均有影响，患者GFR水平越高，动脉狭窄严重程度越低，生存状况越好。 　　【关键词】 肾小球滤过率； 生存状况； 缺血性脑卒中； 动脉血管狭窄 　　【Abstract】 Objective：To investigate the effect of glomerular filtration rate（GFR） on cerebrovascular disease and survival status in patients with cerebral arterial thrombosis.Method：A total of 338 patients with cerebral arterial thrombosis in our hospital from April 2013 to April 2016 were selected as the subjects.The GFR was calculated according to the modification of diet in renal disease（MDRD） equation，and by GFR three quantile，they were divided into 111 cases of GFR low level group，114 cases of GFR middle level group，and 113 cases of GFR high level group.The arterial stenosis severity and survival status（fatality rate，adverse outcome rate and neurological deterioration rate） of three groups were compared.Result：The severity of arterial stenosis in GFR low level group were higher than those of GFR middle level group and GFR high level group，and GFR middle level group were higher than those of GFR high level group，the differences were statistically significant（P0.05）.The fatality rate，adverse outcome rate and neurological deterioration rate of GFR low level group were significantly higher than those of GFR middle level group and GFR high level group，and GFR middle level group were significantly higher than those of GFR high level group，the differences were statistically significant（P0.05）.Conclusion：GFR has an effect on cerebrovascular disease and survival status in patients with cerebral arterial thrombosis，the higher