羟苯磺酸钙联合厄贝沙坦治疗早期糖尿病肾病疗效分析.docVIP

羟苯磺酸钙联合厄贝沙坦治疗早期糖尿病肾病疗效分析 　　【摘要】 目的：分析羟苯磺酸钙联合厄贝沙坦治疗早期糖尿病肾病的临床疗效与价值。方法：选取2014年9月-2015年5月笔者所在医院收治的92例早期糖尿病肾病患者作为研究对象，按患者编号分为对照组和观察组，每组各46例。对照组给予患者厄贝沙坦治疗，观察组采用苯磺酸钙联合厄贝沙坦治疗，疗程均为两个月。治疗前后，分别测量两组各项临床指标，并将结果进行对比分析。结果：治疗前后，两组的空腹血糖（FPG）、血肌酐（Scr）、平均动脉压（MAP）及糖化血红蛋白（HbA1c）水平比较，差异均无统计学意义（P0.05），且组间比较差异无统计学意义（P0.05）；两组治疗后24 h尿白蛋白排泄率（UAER）水平较治疗前均显著下降（P0.05），且观察组下降幅度明显大于对照组（P0.05）；对照组与观察组的总有效率分别是39.13%、80.43%，观察组的总有效率显著高于对照组（P0.05）。结论：给予早期糖尿病肾病患者羟苯磺酸钙联合厄贝沙坦治疗，有助于降低尿白蛋白排泄量，有效提高治疗效果，值得临床大力推广。 　　【关键词】 糖尿病肾病； 羟苯磺酸钙； 厄贝沙坦； 联合治疗 　　中图分类号 R587.2 文献标识码 B 文章编号 1674-6805（2015）29-0024-03 　　Efficacy Analysis of Calcium Dobesilate Combined with Irbesartan in Treatment of the Early Diabetic Nephropathy/ZHAO Cai-ling.//Chinese and Foreign Medical Research，2015，13（29）：24-26 　　【Abstract】 Objective：To analyze the clinical curative effect and value of the calcium dobesilate combined with irbesartan in treatment of early diabetic nephropathy.Method： According to the patient number，92 patients with early diabetic nephropathy in our hospital from September 2014 to May 2015 were divided into the control group and the observation group，46 cases in each group.The control group was received Irbesartan treatment，the observation group was received calcium irbesartan treatment.Treatment with a course of two months.Before and after treatment， the clinical parameters were measured， and the results were analyzed of the two groups.Result： Before and after treatment，the fasting plasma glucose（FPG），serum creatinine （Scr），mean arterial pressure（MAP） and glycosylated hemoglobin（HbA1c） levels of the two groups，which had no significant change（P0.05）， and there was no significant difference between the two groups（P0.05）；after treatment，24 h urinary albumin excretion rate （UAER） levels of the two groups were significantly lower than before treatment（P0.05），and the observation group decreased more significantly than the control group（P0.05）； the total effective rate of the control group and the observation group were 39