西红康治疗早期糖尿病肾病实验研究.docVIP

西红康治疗早期糖尿病肾病实验研究 　　【摘要】 目的：探?西红康治疗早期糖尿病肾病（diabetic nephropathy，DN）的实验研究。方法：62只大鼠中选取50只进行肾切除并一次性腹腔注射50 mg/kg链脲佐菌素（STZ）复制DN大鼠模型，48只造模成功并随机分为模型组、西红康组、开博通组、糖适平组，其余不做任何处理的为正常对照组，每组各12只，连续给药4周，检测并记录大鼠血糖、24 h尿蛋白、肾重/体重、尿素氮（BUN）、肌酐（Scr）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、脂联素及E-选择素含量。结果：模型组24 h尿蛋白、肾重/体重、HbA1c、Scr、BUN、血糖、TC、TG、LDL-C、脂联素及E-选择素含量均较正常对照组升高（P0.01），HDL-C含量较正常对照组降低（P0.01）；西红康组、开博通组、糖适平组的24 h尿蛋白、肾重/体重、HbA1c、Scr、BUN、血糖、TC、TG、LDL-C、脂联素及E-选择素含量均较模型组降低（P0.01），HDL-C含量较模型组升高（P0.01）。结论：西红康能够通过降低DN大鼠尿蛋白、血糖及血脂水平，减少脂联素分泌及E-选择素表达，进而延缓DN大鼠发展。 　　【关键词】 西红康； 糖尿病肾病； 大鼠； 脂联素； E-选择素 　　【Abstract】 Objective：To explore experimental study on xihongkang in treatment of early diabetic nephropathy（diabetic nephropathy，DN）.Method：In 62 rats，50 rats were selected for nephrectomy and intraperitoneal injection of 50 mg/kg streptozotocin（STZ） to replicate the DN rat model，48 rats were randomly divided into model group，xihongkang group，captopril group，gliguidone group，the other without any treatment as normal control group，12 rats in each group，administered continuously for 4 weeks.The concentration of blood glucose，24 h urine protein，kidney weight/body weight，blood urea nitrogen（BUN），creatinine（Scr），glycosylated hemoglobin（HbA1c），total cholesterol（TC），triglyceride（TG），low density lipoprotein cholesterol（LDL-C），high density lipoprotein cholesterol（HDL-C），adiponectin and E-selectin was detected and recorded.Result：The contents of 24 h urine protein，kidney weight/body weight，HbA1c，Scr，BUN，blood glucose，TC，TG，LDL-C，adiponectin and E-selectin of model group were higher than those of normal control group（P0.01），and HDL-C content was lower than that of normal control group（P0.01）.The contents of 24 h urine protein，kidney weight/body weight，HbA1c，Scr，BUN，blood glucose，TC，TG，LDL-C，adiponectin and E-selectin of xihongkang group，captopril group，gliguidone group were lower than those of model group（P0.01），and HDL-C content was higher than that of model group（P0.01）.Conclusi