吡格列酮减轻糖尿病大鼠肾脏损伤及其对肾组织pcx表达的影响-内科学(内分泌与代谢病)专业论文.docxVIP

- - PAGE 2 - 3.4 吡格列酮对糖尿病大鼠尿PCX排泄及肾组织中PCX表达的影响 37 3.4.1 各组大鼠尿PCX排泄动态变化 37 3.4.2 肾组织PCX蛋白表达 38 3.4.3 肾皮质PCX mRNA表达 39 3.5 UPCR分别与UACR和KI的相关性分析 40 4 讨论 ································································································· ··················· 41 4.1 糖尿病肾脏疾病发病机制概述 ··················································· ··················· 41 4.2 糖尿病肾脏疾病和足细胞损伤 ··················································· ··················· 41 4.3 吡格列酮对糖尿病大鼠肾组织的保护作用································ ··················· 42 4.4 吡格列酮对糖尿病大鼠尿PCX排泄及肾组织PCX表达的影响 43 4.4.1 PCX的功能 43 4.4.2 吡格列酮对尿PCX排泄的影响 44 4.4.3 吡格列酮对肾组织PCX蛋白及mRNA表达的影响 44 4.5 吡格列酮保护足细胞的作用机制 ··············································· ··················· 46 4.6 实验中的经验和不足 ··································································· ··················· 49 5 结论 ································································································· ··················· 50 参考文献 ····························································································· ··················· 51 附录 个人简历···················································································· ··················· 63 致谢 ····································································································· ··················· 65 综述 ····································································································· ··················· 66 中英文缩写对照表 缩写 AGEs 英文名称 advanced glyco