西地那非联合低分子肝素钙治疗慢性阻塞性肺病合并肺心病疗效观察.docVIP

西地那非联合低分子肝素钙治疗慢性阻塞性肺病合并肺心病疗效观察 　　[摘要] 目的 探讨西地那非联合低分子肝素钙治疗慢性阻塞性肺病（慢阻肺）合并肺心病的疗效。方法 选取60例慢阻肺合并肺心病患者按随机数字表均分为两组。研究组予西地那非联合低分子肝素钙，对照组予西地那非治疗。疗程3个月，观察治疗前后两组平均肺动脉压（PAH）、右心室流出道直径（RVOT）、动脉氧分压（PaO2）和临床症状改善时间（T）。结果 治疗后研究组PAH、RVOT缩短，PaO2升高。对照组PAH、RVOT稍缩短，PaO2升高。治疗后两组ΔPaO2、ΔPAH、ΔRVOT、ΔT差异有统计学意义（P0.05）。结论 西地那非联合低分子肝素钙治疗慢阻肺合并肺心病能降低肺动脉压力，改善心功能等临床症状。 　　[关键词] 慢性阻塞性肺病合并肺心病；肺动脉高压；右室流出道直径；动脉氧分压；西地那非；低分子肝素钙 　　[中图分类号] R541.5[文献标识码] B[文章编号] 1673-9701（2014）16-0146-03 　　 　　The curative effect observation of sildenafil combined low molecular heparin calcium treatment for chronic obstructive pulmonary disease (COPD) with cor pulmonal 　　SHAO Haiyan CHEN Junfeng 　　Department of Pneumology, Wenling County First Peoples Hospital of Zhejiang Province, Wenling 317500, China 　　[Abstract] Objective To study the curative effect of combining sildenafil with low molecular heparin calcium treatment for chronic obstructive pulmonary disease(COPD) with cor pulmonale. Methods Sixty cases of COPD with cor pulmonale were divided into two groups according to the random number table. The research group were given sildenafil with low molecular heparin calcium, while the control group were treated with sildenafil. After 3 months treatment, the mean pulmonary artery pressure (PAH), the right ventricular outflow tract (RVOT) diameter, the arterial oxygen partial pressure (PaO2), the parameters and the clinical symptoms improved time (T) were observed before and after treatment of the two groups. Results After treatment, the PAH were reduced, the RVOT were shortened, the PaO2 were increased in the research group. After treatment, the PAH, RVOT were slightly shorter, the PaO2 were higher in the control group. Before treatment,there were no statistically significant differences of parameters between the two groups (P0.05). After treatment, the ΔPaO2, ΔPAH, ΔRVOT, ΔT were differences between the two groups. The differences were statistically significant(P0.05). Conclusion Combining sildenafil with low molecular