阿托伐他汀联合参芎注射液治疗慢性阻塞性肺疾病合并肺动脉高压疗效观察.docVIP

阿托伐他汀联合参芎注射液治疗慢性阻塞性肺疾病合并肺动脉高压疗效观察 　　[摘要] 目的 观察阿托伐他汀联合参芎注射液治疗慢性阻塞性肺疾病合并肺动脉高压的疗效。 方法 选择2013年1月～2014年4月在我院治疗的肺动脉高压患者60例，分为联合组和对照组，每组30例，对照组予氧疗、抗炎、祛痰、小剂量强心剂、利尿、止咳、平喘、纠正酸碱失衡及电解质紊乱等常规对症治疗。联合组在此治疗基础上联用阿托伐他汀20 mg口服，每晚一次，连用3个月。参芎注射液200 mL静脉滴注，每日1次，连用2周。比较两组治疗后的临床疗效、治疗前后肺功能指标FEV1、FVC的变化情况。 结果 联合组治疗后的总有效率显著高于对照组，两组疗效比较差异有统计学意义（83.33% vs 60.00%，P0.05）；治疗后，联合组和对照组患者的肺功能指标FEV1、FVC分别较治疗前显著升高，且联合组治疗后的FEV1（0.92±0.12 ）L、FVC（1.93±0.19）L，分别显著高于对照组治疗后的肺功能指标FEV1、FVC，组间比较差异有统计学意义（P0.05）。 结论 阿托伐他汀联合参芎注射液治疗慢性阻塞性肺疾病合并肺动脉高压疗效确切，可以显著改善肺功能，值得推广和应用。 　　[关键词] 慢性阻塞性肺疾病；肺动脉高压；阿托伐他汀；参芎注射液 　　[中图分类号] R563.9 [文献标识码] B [文章编号] 1673-9701（2015）29-0032-04 　　The curative effect of atorvastatin combined with Shenxiong injection in treatment of chronic obstructive pulmonary disease complicated with pulmonary hypertension 　　LUO Wei1 WU Lianpin2 　　1.Department of Internal Medicine， Shangyu the Second Peoples Hospital of Shaoxing City in Zhejiang Province， Shaoxing 312365， China； 2.Department of Cardiology， the Second Hospital Affiliated to Wenzhou Medical University， Wenzhou 325000， China 　　[Abstract] Objective To explore the effect of atorvastatin combined with Shenxiong injection in treatment of chronic obstructive pulmonary disease with pulmonary arterial hypertension. Methods From January 2013 to April 2014 in our hospital， 60 cases pulmonary arterial hypertension were divided into combined group and control group， the control group was treated with oxygen therapy， anti-inflammatory， expectorant， small dose cardiotonic， diuretic， cough， asthma， correct acid-base imbalance and electrolyte disturbance such as conventional symptomatic treatment. The combined group combined with atorvastatin 20 mg， once every night， for 3 months，and Shenxiong injection 200 mL intravenous drip， one time daily， for 2 weeks. The clinical effect and the changes of FVC and FEV1 of the lung function index before and after treatment were compared between two groups. Results The total effective rate of combined group was signific