阿奇霉素序贯疗法对儿童肺炎支原体衣原体感染疗效分析.docVIP

阿奇霉素序贯疗法对儿童肺炎支原体衣原体感染疗效分析 　　【摘要】 目的：阿奇霉素序贯疗法对儿童肺炎支原体（Mp）、肺炎衣原体（Cp）感染的疗效分析，提出可行的治疗措施。方法：对732例肺炎患儿采用血清酶联免疫吸附试验（ELISA）进行血清学检测MpIgM,CpIgM，总结阿奇霉素序贯疗法的疗效。结果：其中237例肺炎患儿MpIgM及 CpIgM阳性，并将237例Mp、Cp感染的患儿均采用退热止咳化痰对症治疗同时予以阿奇霉素序贯治疗 。治疗中密切观察患儿体温变化和临床症状及药物不良反应。结论：阿奇霉素序贯疗法治疗Mp的疗效明显优于Cp(P0.01)。对Mp及Cp组组内疗效比较大年龄组明显高于小年龄组(P0.01)。阿奇霉素序贯治疗疗效确切，值得推广。 　　【关键词】 儿童肺炎；Mp；Cp；阿奇霉素序贯疗法 　　 　　Azithromycin sequential therapy in children: clinical analysis of Mycoplasma infection 　　HUANG ying 　　( xindu district hospital in Chengdu Sichuan, Chengdu 610500) 　　 　　【Abstract】 purpose: azithromycin sequential therapy on Mycoplasma pneumonia in children (Mp), Chlamydia pneumoniae (Cp) efficacy of analysis, propose feasible treatment measures. Methods: To 732 children with pneumonia serum enzyme-linked immunosorbent assay (ELISA) for serological detection MpIgM,CpIgM, summary of clinical efficacy of azithromycin sequential therapy. Results: among the 237 cases of pneumonia in children with MpIgM and CpIgM-positive and 237 cases of infection with Mp and Cp are made of antipyretic relieving cough and reducing sputum of children with syndromic and azithromycin sequential therapy. Close observation in the treatment of children with body temperature and clinical symptoms and adverse drug reactions. Conclusion: azithromycin sequential therapy in the treatment of Mp much better than the Cp (P0.01). On Mp and Cp group comparison of large age groups above the small age group within the Group (P0.01). Therapeutic effect of azithromycin sequential therapy in exact, worth promoting. 　　【Keywords】 children; Mp; Cp; azithromycin sequential therapy 　　 　　肺炎是全世界儿童最常见的疾病，[1]据世界卫生组织（WHO）最新估计，全球每年大约有1.56亿为新发病例，其中1.51亿病例发生在发展中国家。中国新发病例0.21亿仅次于印度0.43亿。其中7%-13%的患儿病情严重。肺炎是5岁以下儿童死亡首要原因。每年有200万以上儿童死于肺炎。（1）而近年来支原体衣原体感染在临床上呈上升趋势。其临床表现特殊，免疫紊乱明显。且运用大环内脂类抗生素疗效较差。为了解儿童肺炎之病原中肺炎支原体（Myxoplasma pneumon iae,Mp）肺炎衣原体感染(Chlamydia pneumoniae,Cp)的分布情况，探讨其流行规律，制定可行的治疗措施。我们采用血清酶联免疫吸附试验（ELISA）进行血清学检测MpIgM,CpIgM，对742例肺炎患儿进行了Mp、Cp的检测。并将阳性患儿采用阿