阿托伐他汀治疗对急性冠脉综合征患者血浆CRP和IL6水平影响.docVIP

阿托伐他汀治疗对急性冠脉综合征患者血浆CRP和IL6水平影响 　　【摘要】 目的 探讨阿托伐他汀干预对急性冠脉综合征(ACS)患者血浆C-反应蛋白(CRP)和白介素-6(IL-6)水平的影响。方法 采用随机开放法将62例ACS分为阿托伐他汀治疗组和常规对照组进行为期4周的干预，分别测定治疗前及治疗后2周患者血浆CRP和IL-6的浓度变化，比较治疗前后的血浆CRP及IL-6水平变化。结果 急性冠脉综合征患者血清CRP及IL-6水平明显升高,治疗4周后，阿托伐他汀治疗组血浆CRP及IL-6水平均明显下降，而常规对照组CRP和IL-6水平无明显变化。结论 ACS的发生与机体炎症反应激活有关。阿托伐他汀能够降低血浆CRP和IL-6水平，在ACS的治疗中具有重要作用。? 　　【关键词】 急性冠脉综合症；C反应蛋白；白介素-6；阿托伐他汀?? 　　The change of serum CRP and IL-6 in patients with ACS and the effect of atorvastatin treatment on levels of serum CRP and IL-6 　　FANG Jian-ping.Shandong Sanjian Hospital,Jinan 250014,China? 　　【Abstract】 Objective To discuss the effect of atorvastatin treatment on levels of serum C-reactive protein (CRP) and interleukin-6(IL-6) in patients with acute coronary syndrome. Methods 62 patients with acute coronary syndrome were randomly divided into two groups. The treatment group were treated with atorvastatin and the control group were treated with convention medicine. Before and after two weeks treatment the symptoms were observed, the CRP and IL-6 were analyzed. Results After being treated two weeks ，the CRP and IL-6 decreased distinctly，the difference had statistical significance(P0.01)； the levels of CRP and IL-6 were lower in treatment group than those in control group，the difference had statistical significance(P0.01)．Conclusion CRP and IL-6 participated in the pathogenesis of acute coronary syndrome． Atorvastatin Treatment has significant effect on inflammatory reaction and improving prognosis，can treat acute coronary syndrome preferably.? 　　【Key words】 Acute coronary syndromes；C-reactive protein ; Interleukin-6(IL-6); Atorvastatin 　　 　　他汀类药物是当前调脂药物中最有效的药物，具有独立于降脂作用之外的抗炎作用。为进一步评判该药物治疗急性冠脉综合症的确切疗效，探讨其作用机制，进行了临床对照观察，并观察了与冠状动脉疾病的发生、发展关系密切的C-反应蛋白原(CRP)和血清白细胞介素6(IL-6)水平变化，总结报告如下。? 　　1 对象和方法? 　　1．1 一般资料 所有观察对象均为2005年10月至2007年10月住院治疗的62例急性冠脉综合症患者。采用随机方法，将入选对象分为阿托伐他汀治疗组和常规对照组，2组各入选31例。其中男35例，女27例，年龄42～76岁，平均52．6岁。发病到入院平均时间（8．2±4．6）h。不典型心绞痛28例，无Q波急性心梗13例，不稳定性心绞痛21例。入选标准：均符合欧洲心脏病学会(ESC)和美国心脏病学会(AC