一二章细胞适应、损伤与修复演示文稿.ppt

Sequel: Devascularization-fibroplasia: atrophy and obliteration of blood vessels Forming pale and avascular scar tissue II. Scar benefit harmful: a.Contraction b. Synechia c. Excessive proliferation ‘Keloid’ formation excessive formation of collagenous Section IV Wound Healing I. Healing of a skin wound The process of healing of a skin wound depends on the size of the defect. ( I ). The course of wound healing 1. Change of early period: removal of inflammatory 2. Wound contraction: 2-3 days The contraction force is generated by myofibroblasts of granulation tissue. 3. Proliferation of granulation tissue and formation of scar 3th, 5-6 days : collagenization 1 month : complete formation of scar 4. Epidermis regeneration ( II ). Types of wound healing comparison of two types of wound healing Characteristic Healing by first intention Healing by second intention defect size small large suture usually, yes no infection no yes amount of necrotic tissue small large amount of granulation tissue small large scar size very small large rate of healing rapid slow complication rarely keloid II. Healing of bone fracture Traumatic bone fracture Pathological bone fracture Healing of bone fracture consists of 4 steps hematoma fibrous callus osseous callus callus forming forming forming reconstruct III. Factors influence wound healing ( I ). Systemic factors 　 1．Aging 　 2. Nutrition: nutritional imbalance protein 甲硫氨酸、蛋氨酸等含硫 氨基酸 deficiency, Vitamin C, or Zn deficiency ( II ). Local factors 1. infection and foreign body 2. local vascula