动脉瘤性蛛网膜下腔出血致早期心肌损伤的相关研究-外科学专业论文.docxVIP

必要进行常规 ECG 、心肌损伤标记物检查，以便早期评估心肺功能情况， 及时监护治疗。 关键词:动脉瘤性蛛网膜下腔出血;心肌损伤;心电图:心肌损伤标 记物 A study on early myocardial injury after aneurysmal subarachnoid hemorrhage Abstract: Objective: To investigate the impact of related factors to myocardial damage and mortality through observing the changes of electrocardiographic and increased concentrations of serial cardiac markers in patients after aneurysmal subarachnoid hemorrhage (aSAH) . Methods : Consecutive patients admitted with aSAH were diagnosed by CTAlDSA and enrolled in the Neurosurgery department of Luzhou Medical Collage between July 2010 and January 2011.Predictor variables reflecting demographic (age， sex，hunt-hess scre，fisher score) were recorded. Serial cardiac troponin 1， creatine kinase-MB ，myoglobin measurements and ECG were performed on days 1，3，and 7 after enrollment. Dichotomous variables (sex，age，fisher grade group，hunthess grade group) were examined with the chi(2) test or the Fisher exact test to determine whether ECG abnormalities and increased concentrations of serial cardiac markers show significant difference between variables groups. The incidence of each polymorphism on the risk of developing electrocardiographic (ECG) abnormalities and increased concentrations of cardiac markers was quantified using multivariable logistic regression. Results: There wωno significant difference in the groups(a肘， sex，Hunt-Hess score，Fisher score) on ECG abnormalities and increased concentrations of MYO. But，there was significant difference in the groups(Hunt-Hess score，Fisher score) on the increased concentrations of 丁nI and CK-MB. By multivariate logistic regression ，age，sex，hunt-hess score， fisher score are not an independent risk factor of ECG abnormalities and increased concentrations of cardiac markers of patients with aneurysmal SAH. Conclusion:ECG changes and increase of cardiac tr叩onin I，creatine kinase巾俑，myoglobin were common and irreversible in patients with aneurysmal SAH，but for more time.