甘精胰岛素与阿卡波糖联合治疗2型糖尿病疗效观察.docVIP

甘精胰岛素与阿卡波糖联合治疗2型糖尿病疗效观察 　　[摘要] 目的：研究甘精胰岛素和阿卡波糖合用治疗2型糖尿病（T2DM）的疗效及该治疗方案对胰腺β细胞分泌功能的改善。方法：90例T2DM患者均给予甘精胰岛素和阿卡波糖治疗16周，检测治疗前及治疗16周后的空腹血糖值（FPG）、餐后2 h血糖值（2 h PG）、糖化血红蛋白（HbA1c）、空腹C肽（FCP）、餐后C肽（PCP）的变化。结果：经16周治疗后患者FPG、2 h PG、HbA1c分别下降为（6.91±1.50）mmol/L（t=1.669）、（8.28±2.12）mmol/L（t=2.136）、（6.51±1.03）%（t=1.663），较治疗前明显下降，差异有统计学意义（P＜0.05）；治疗后患者FCP、PCP分别上升为（3.42±0.42）μg/L（t=2.178）、（3.78±0.32）μg/L（t=2.752），较治疗前明显上升，差异有统计学意义（P＜0.05）。结论：甘精胰岛素和阿卡波糖合用治疗T2DM降糖效果好，并具有改善胰腺β细胞的内分泌功能的作用。 　　[关键词] 甘精胰岛素；阿卡波糖；2型糖尿病 　　[中图分类号] R587.2 [文献标识码] A [文章编号] 1673-7210（2012）01（a）-063-02 　　 　　Therapeutic efficacy of Glargine Insulin combined with Acarbose in the treatment of patients with type 2 diabetes mellitus 　　ZHUANG Xiuyi, XIE Yingcai 　　Department of Pharmacy, the Affiliated Hospitial of Guangdong Medical College, Guangdong Province, Zhanjiang 524000, China 　　[Abstract] Objective: To study therapeutic efficacy of Glargine Insulin combined with Acarbose in the treatment of type 2 diabetes mellitus (T2DM) and the efficacy of secretory function of pancreatic β-cell protection and improvement. Methods: 90 patients with T2DM were given Glargine Insulin and Acarbose after 16 weeks of treatment. The change of fasting plasma glucose (FPG), postprandial 2 h blood glucose (2 h PG), glycosylated hemoglobin (HbA1c), fasting C peptide (FCP), postprandial C peptide (PCP) were detected after 16 weeks of treatment. Results: After 16 weeks of treatment in patients with FPG, 2 h PG, HbA1c decreased as the (6.91±1.50) mmol/L (t=1.669), (8.28±2.12) mmol/L (t=2.136), (6.51±1.03)% (t=1.663) descent, obviously after therapy, the differences were significant (P＜0.05). FCP, PCP were increased to (3.42±0.42) μg/L (t=2.178), (3.78±0.32) μg/L (t=2.752), both were higher than before treatment, there were significant differences (P＜0.05). Conclusion: The treatment of Glargine Insulin combined with Acarbose in T2DM has a good hypoglycemic effect and can improve the endocrine function of pancreatic β-cell. 　　[Key words]