冠心病患者血清脂蛋白相关磷脂酶与C反应蛋白改变及临床意义.docVIP

冠心病患者血清脂蛋白相关磷脂酶与C反应蛋白改变及临床意义 　　[摘要]目的 探讨血清脂蛋白相关磷脂酶A2（LP-PLA2）和C反应蛋白（CRP）在冠心病发病中的作用及临床价值。方法 采用双抗夹心ELISA法测定120例冠心病患者和35例健康体检者血清LP-PLA2和CRP水平。 结果 冠心病组血清LP-PLA2、CRP水平均显著高于对照组（t=4.157，11.152，P＜0.01）；在冠心病不同临床类型患者中，AMI组血清LP-PLA2、CRP水平显著高于UAP组、SAP组（t=3.509，3.973，4.453，7.510，P均＜0.01），UAP组血清LP-PLA2、CRP水平显著高于SAP组（t=2.998，4.466，P＜0.05）；血清LP-PLA2和CRP水平无相关性（r=0.067，P＞0.05）。结论 LP-PLA2和CRP同参与了动脉粥样硬化的炎症反应，在冠状动脉粥样硬化的进程中扮演了重要的角色。 　　[关键词] 脂蛋白相关磷脂酶A2；C反应蛋白；冠心病；血清 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701（2011）24-138-02 　　 　　Changes of Serum LP-PLA2 and CRP in Patients with Coronary Heart Diseases and Its Clinical Significance 　　ZHAO Zhufei1 WANG Fei2 　　1.Medical Department， Second Peoples Hospital of Zhuji City， Zhuji 311811，China； 2.Departmen of Emergenc， Traditional Chinese Medicine Hospitaln of Zhuji City， Zhuji 311811，China 　　[Abstract] Objective To investigate the change of serum LP-PLA2 and CRP in patients with coronary heart diseases （CHD） and its clinical significance. Methods The serum LP-PLA2 and CRP level of 120 cases of CHD patients and 35 cases of healthy subjects were measured by ELISA. Results The serum LP-PLA2 and CRP levels of the CHD group were higher than the control group， compared the difference was significant （t=4.157，11.152，P＜0.01）；In CHD patients of different clinical types， the serum LP-PLA2 and CRP levels of AMI group were higher than the UAP group and SAP group， the difference was significant （t=3.509，3.973，4.453，7.510，P＜0.01）；The serum LP-PLA2 and CRP levels of UAP group were higher than the SAP group， the difference was significant （t=2.998，4.466，P＜0.05）； The serum LP-PLA2 and CRP levels was no significantly correlated （r=0.067，P＞0.05）. Conclusion The serum LP-PLA2 and CRP levels participate in the atherosclerotic inflammatory response and play important role in the incidence of in the process of coronary atherosclerosis. 　　[Key words] LP-PLA2； CRP； Coronary heart diseases； Serum 　　 　　冠心病是严重威胁人类健康和生命的心血管疾病，在全界范围内其发病率和死亡率均居首位，近年来发病率呈年龄化和升高趋势[1]