全亲水无规共聚物P(NIPAM-co-AA)pH和温度双重刺激.PDF

物理化学学报(Wuli Huaxue Xuebao) 1290 Acta Phys. -Chim. Sin. 2014, 30 (7), 1290-1296 July [Article] doi: 10.3866/PKU.WHXB201405092 全亲水无规共聚物P(NIPAM-co-AA)的pH 和温度双重刺激 响应性水相自组装 陈韩婷 樊 晔 方 云* (江南大学化学与材料工程学院, 食品胶体与生物技术教育部重点实验室, 江苏无锡214122) 摘要: 从N-异丙基丙烯酰胺(NIPAM)和丙烯酸(AA)单体合成了一种全亲水无规共聚物P(NIPAM-co-AA), 实 验发现该聚合物在水相中可以产生pH 或温度双重刺激响应性自组装. 采用透射电子显微镜(TEM)观察了自组 装体的形貌, 采用动态光散射(DLS)和静态光散射(SLS)观察了其粒径及粒径分布. 测定了该聚合物水溶液的最 低临界溶解温度(LCST)及其zeta 电位随pH 的变化, 通过分析NIPAM 和AA 两种链节的质子化状态随温度和 pH 变化的趋势, 阐释了其在水相中产生双重响应性自组装的推动力; 并结合傅里叶红外(FT-IR)光谱测定自组 装体表面富集基团的结果, 进一步阐释了不同环境下自组装体的微结构. 这类全亲水无规共聚物的合成方法简 单, 具有pH 和温度双重响应性, 其全水相中的刺激响应性自组装行为在药物释放等方面具有潜在的应用价值. 关键词: 全亲水无规共聚物; N-异丙基丙烯酰胺; 丙烯酸; 刺激响应性; 自组装 中图分类号: O648 Dual pH- and Thermo-Responsive Self-Assembly of the P(NIPAM-co-AA) Hydrophilic Random Copolymer in Pure Aqueous Solution CHEN Han-Ting FAN Ye FANG Yun* (Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, Jiangsu Province, P. R. China) Abstract: The random poly(N- isopropylacrylamide-co-acrylic acid) copolymer (P(NIPAM-co-AA)) was synthesized and its stimuli-responsive self-assembly in pure aqueous solution was investigated. P(NIPAM- co-AA) is a dual pH- and thermo-responsive hydrophilic random copolymer because it can self-assemble in pure aqueous solution in response to the stimuli of pH and temperature. The morphologies of P(NIPAM-co- AA) assemblies were imaged by transmission