第三、四章药效学、影响因素.pptVIP

半数有效量（median effect dose, ED50） 引起50%的实验动物出现阳性反应的药物剂量。 ED50 is the dose of a drug at which 50% of the population occur positive reaction. The lower the ED50, the more potent the drug. 反应数% 死亡数% 对数剂量 对数剂量 半数有效量（median effective dose , ED50 ) 半数致死量（median lethal dose , LD50 ) 半数致死量（median lethal dose, LD50） 引起50%实验动物死亡的药物剂量 LD50 is the dose of a drug to cause 50% of the experimental animals to die. The lower the LD50, the more toxic the drug. LD50 is the index to measure the toxicity of drug, but it is not a exactly one, the therapeutic index should be considered.