非布司他治疗痛风的临床效果研究.docVIP

非布司他治疗痛风的临床效果研究 　　[摘要] 目的 探讨非布司他治疗痛风的临床效果。 方法 将我院选取2014年1月～2015年12月收治的60例急性发作期痛风患者随机分为观察组、对照组，每组30例，所有患者均保持痛风饮食及常规治疗，观察组治疗开始就予非布司他40 mg，1次/d口服；对照组在关节肿痛缓解后再予别嘌醇100 mg，3次/d，连续治疗8周，比较两组治疗前后血尿酸的变化情况。 结果 治疗8周后，两组患者的血尿酸水平分别较治疗前显著降低，观察组患者治疗后的血尿酸水平 （359.16±82.12） mmol/L，显著低于对照组，差异具有统计学意义（P0.05）。 结论 非布司他较别嘌醇更能有效降低痛风患者的尿酸水平，改善患者的临床症状及提高疗效，且安全性较好，值得推广和应用。 　　[关键词] 痛风；非布司他；别嘌醇；血尿酸 　　[中图分类号] R589.7 [文献标识码] B [文章编号] 1673-9701（2016）26-0103-03 　　Clinical effect of febuxostat in treatment of gout 　　MIAO Yi ZHU Jianqin 　　Department of Immunology， Jingjiang City Peoples Hospital in Jiangsu Province， Jingjiang 214500， China 　　[Abstract] Objective To investigate the clinical effect of febuxostat in treatment of gout. Methods A total of 60 patients with gout in our hospital from January 2014 to December 2015 were randomly divided into observation group and control group， each group of 30 cases， all enrolled patients were maintained gout diet and conventional therapy， the observation group was treated with febuxostat 40 mg， 1 time/d， po， the control group after joint pain relief was treated with allopurinol 100 mg， 3 times/d. Two groups were all continuous treatment for 8 weeks. The changes of serum uric acid levels were compared between the two groups. Results After 8 weeks of treatment， the serum uric acid levels of the two groups were significantly lower than before treatment， and the difference was significant（P0.05）. After treatment，the serum uric acid level of observation group was（359.16±82.12） mmol/L， was significantly lower than the control group，and the difference was significant（P0.05）. Conclusion Compared with allopurinol，febuxostat in treatment of gout can effectively reduce the level of uric acid in patients with gout，improve the patients clinical symptoms and improve the curative effect， good security， it is worth popularized and applied. 　　[Key words] Gout； Febuxostat； Allopurinol； Blood uric acid 　　痛风（gout）的发病主要是由于嘌呤代谢紊乱和（或）尿酸排泄减少所致[1]，近年来随着人们生活水平的不断提高，其发病率呈现逐年上升