高血糖对慢性阻塞性肺疾病患者肺功能的影响.docVIP

高血糖对慢性阻塞性肺疾病患者肺功能的影响 　　[摘要]目的 探?高血糖对慢性阻塞性肺疾病（COPD）患者急性加重期和临床缓解期肺功能影响的特点。方法 选取2015年6月～2016年9月我院呼吸内科收治的慢性阻塞性肺疾病急性加重期（AECOPD）患者125例，根据空腹血糖水平（FBG）分为单纯AECOPD组（对照组）、AECOPD伴高血糖组（观察组）。检测患者入院时和出院后6个月时的肺功能指标：第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、肺总量（TLC）、肺一氧化碳弥散量（DLCO），并分析FBG与肺功能指标的相关性。结果 ①入院时和出院后6个月，观察组TLC、DLCO均低于对照组，差异有统计学意义（P0.05）。结论 AECOPD患者随着血糖升高，限制性通气功能障碍和弥散功能障碍加重，而无明显的阻塞性通气功能障碍，提示AECOPD患者住院期间应严格控制血糖。 　　[关键词]慢性阻塞性肺病；肺功能；高血糖 　　[中图分类号] R563 [文献标识码] A [文章编号] 1674-4721（2017）10（c）-0024-03 　　The impact of elevated blood glucose on pulmonary function in patients with COPD 　　ZHENG Hong-yan WANG Zhi-gang WANG Mei▲ 　　Department of Respiratory Medicine，the People′s Hospital Affiliated of Quanzhou Medical College，FuJian Province， Quanzhou 362000，China 　　[Abstract]Objective To study the effect of hyperglycemia on pulmonary function of chronic obstructive pulmonary disease （COPD）patients in acute exacerbation stage and clinic remission stage.Methods 125 acute exacerbation of chronic obstructive pulmonary disease（AECOPD）patients hospitalized our hospital in Department of Respiratory Medicine from June 2015 to September 2016 were selected.According to the fasting blood glucose level（FBG），the 125 cases were divided into two groups.Forced expiratory volume in one second（FEV1），forced vital capacity（FVC），total lung capacity（TLC），diffusion capacity for carbon monoxide（DLCO） were measured at admission and 6 months after discharge.The relationship of FBG and pulmonary function was analyzed.Results ①The levels of TLC and DLCO were both significantly lower in the observation group than those in the control group（P0.05）.Conclusion Lung diffusing capacity and restrictive ventilatory dysfunction of AECOPD with hyperglycemia are further damaged，obstructive ventilatory disturbance is not damaged.Making a strict glucose control on AECOPD patients in hospitalization is necessary. 　　[Key words]Chronic Obstructive Pulmonary Disease；Pulmonary function；Hyperglycemia 　　慢性阻塞性肺疾病（COPD）是一种以持续气流受限为特征的肺部疾病，发病率、