黄粉虫油对高脂血症小鼠血脂水平及抗氧化能力的影响-食品科学.PDF

※营养卫生 食品科学 2011, Vol. 32, No. 05 263 张建新，张立佳，王临宾，林福壁，朱 杰 (西北农林科技大学食品科学与工程学院，陕西 杨凌 712100) 目的：探讨黄粉虫油对高脂血症小鼠血脂水平及抗氧化能力的影响。方法：以高脂饲料喂养雄性ICR 小鼠， 建立高脂血症模型，以不同剂量(5 、10、20mL/(kg ·d)) 的黄粉虫油对小鼠进行灌胃，观察各实验组小鼠血脂水平 和肝脏抗氧化能力的变化情况。结果：黄粉虫油能显著降低高脂血症小鼠血清总胆固醇(TC) 、甘油三酯(TG) 、低密 度脂蛋白胆固醇(LDL-C)浓度，升高高密度脂蛋白胆固醇(HDL-C) 的浓度，同时动脉粥样硬化指数(AI) 亦显著降低； 黄粉虫油能降低小鼠肝脏丙二醛(MDA)含量，增加肝脏过氧化氢酶(CAT)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化 物酶(GSH-Px) 的活性，提高肝脏总抗氧化(T-AOC)能力。结论：黄粉虫油具有调节血脂和增强抗氧化功能的作用。 黄粉虫油；高脂血症；血脂水平；抗氧化 Effect of Tenebrio molitor Oil on Blood Lipid and Antioxidant Function in Hyperlipidemic Mice ZHANG Jian-xin ，ZHANG Li-jia ，WANG Lin-bin ，LIN Fu-bi ，ZHU Jie (College of Food Science and Engineering, Northwest AF University, Yangling 712100, China) Abstract ：Objective: To explore the effect of Tenebrio molitor oil on blood lipid and antioxidant function in ICR male mice with hyperlipidemia. Methods: High fat diet was used to create a hyperlipidemic model. Fifty healthy male ICR mice were randomly divided into 5 groups of 10 each: normal control group (fed basal diet), high fat model group (fed high fat diet) and low-, middle- and high-dose Tenebrio molitor oil groups (fed high fat diet and administered intragastrically with Tenebrio molitor oil at doses of 5, 10 mL/(kg ·d) and 20 mL/(kg ·d), respectively). After 30 consecutive days of intragastric administration, all the mice were measured for their body weight, liver index, blood lipid levels and antioxidant function in liver. Results: Tenebrio molitor oil could reduce serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels as well as arteriosclerosis index (AI), and increase high-density lipoprotein cholesterol (HDL-