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- 2018-10-13 发布于福建
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冠心病患者颈动脉粥样硬化发生状况及相关因素的研究
冠心病患者颈动脉粥样硬化发生状况及相关因素的研究
【摘要】 目的 探讨冠心病患者颈动脉粥样硬化发生状况及相关因素。方法 250例患者, 均进行冠状动脉造影检查, 根据造影结果分为冠心病组(140例)和非冠心病组(110例), 观察两组颈动脉、颈内动脉及颈外动脉内径、内-中膜厚度(IMT)以及斑块积分、Gensini积分情况。再将250例患者按照年龄段分为三组, 其中中年期组(45~55岁)80例、老年前期组(56~65岁)86例、老年期组(66~78岁)84例, 观察三组性别及糖尿病、高尿酸血症、斑块、高血压病、冠心病、脑梗死发生情况, 依据线性回归观察高血压病、高尿酸血症、冠心病、糖尿病、脑梗死的OR值。结果 冠心病患者颈动脉、颈内动脉及颈外动脉内径、IMT以及斑块积分、Gensini积分均高于非冠心病组, 差异均具有统计意义(P0.05);三组斑块、高血压病、冠心病、脑梗死发生率比较差异具有统计学意义(P0.05)。针对各因素进行的线性回归分析, 中年期糖尿病、脑梗死纳入回归方程, 其中糖尿病的OR=14.939, P0.05;脑梗死的OR=11.432, P0.05。老年前期高血压病、糖尿病、冠心病纳入回归方程, 其中高血压病的OR=3.014, P0.05;冠心病的OR=2.956, P0.05;糖尿病的OR=6.907, P0.05。老年期高血压病、脑梗死、高尿酸血症、冠心病纳入回归方程, 其中高血压病的OR=6.047, P0.05;脑梗死的OR=7.590, P0.05;高尿酸血症的OR=5.499, P0.05;冠心病的OR=3.712, P0.05。结论 针对冠心病及由此造成的心脑血管疾病患者, 应该进行定期的颈动脉超声检查, 及时的预防和诊治, 以降低中老年人高血压、脑梗死等疾病的发生率。
【关键词】 冠心病;颈动脉粥样硬化;相关因素
DOI:10.14163/j.cnki.11-5547/r.2017.05.009
Study on occurrence of carotid atherosclerosis in coronary heart disease patients and its related factors SU Ren. Zhengzhou University Affiliated Central Hospital, Zhengzhou 450000, China
【Abstract】 Objective To explore the occurrence of carotid atherosclerosis in coronary heart disease patients and its related factors. Methods A total of 250 patients all received coronary angiography examination, and they were divided by angiography outcomes into coronary heart disease group (140 cases) and non coronary heart disease group (110 cases). Observation were made on carotid artery, internal carotid artery and external carotid artery diameter, intima-media thickness (IMT), plaque integral and Gensini score in two groups. 250 patients were divided by age groups into three groups, including middle-aged group (45~55 years old, 80 cases), pre-aged group (56~65 years old, 86 cases) and aged group (66~78 years old, 84 cases). Observation was made on genders and occurrence of diabetes, hyperuricemia, plaque, hypertension, coronary heart disease and cerebral infarction in three groups. OR value was observed in hypertension, hyperuricemia, coronary
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