功能性脂类讲解材料.ppt

PUFA;●AA is the precursors of Eicosanoids: Prostaglandins and leukotrienes are locally acting, hormone-like lipids derived from dietarily essential unsaturated fatty acids that are important drug targets Actions of prostaglandins include: inflammatory, pain/fever, blood clotting (via control of platelet-endothelial cell interactions), intestinal, renal, uterine effects Actions of leukotrienes include: mainly hypersensitivity and allergic reactions;Synthesis of Eicosanoids;;Synthesis of Prostaglandin;PGH2 central intermediate (Head of pathway);Leukotriene Biosynthesis;Leukotriene Biosynthesis (Cont’d);Aspirin, Indomethacin, Ibuprofen;Anti-inflammatory glucocorticoids inhibit phospholipase A2 and, therefore, prevent both prostaglandin and leukotriene formation Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX), and thus prevent only prostaglandin/thromboxane synthesis Zyflo inhibits lipoxygenase to preclude only leukotriene synthesis; Accolate is a selective leukotriene receptor antagonist (blocker) ;Cyclooxygenase (COX) Inhibitors;COX-2 Selective Inhibitors;Leukotriene Biosynthesis Inhibition;Function of Prostaglandins;Function of Prostaglandins;Biological activities of leukotrienes;Function of AA;Liver and Gallbladder Inflammation Nerve Cell Division ;Application;Application;Animal experiment results;AA的产业化技术路线;ω-FA ;ω-3 PUFA;ω-6 and ω-3 synthesize;Eicosanoids synthesis;AA;The eicosanoids and their biosynthetic origins. B) Synthesis from ?-3 precursors ;ω-FA also leads to production of PGI3 and TXA3 PGI3 production is favored, and it also has much greater intrinsic activity (than its TXA3 counter-hormone) to favor vasodilation and platelet disaggregation with a reduced risk of thrombosis (blood clotting). This explains why ?-3 dietary fatty acids prevent vascular disease and heart attacks ;Control of platelet aggregation. Suppression of platelet aggregation by drug or dietary intervention ;ω-6 promote TXA2 synthesizing ω-3 promote TXA