超排卵中卵泡发育不均匀不同处理方法的临床观察-妇产科学专业论文.docxVIP

华中科技大学硕士学位论文 华 中 科 技 大 学 硕 士 学 位 论 文 PAGE 4 PAGE 4 undergo IVF/ICSI treatments using long GnRH agonist protocols for controlled ovarian hyperstimulation in Reproductive Medicine Center in Tongji Hospital with follicles presented noticeable size heterogeneities and difference of diameter reached 2mm between dominant follicle and subordinate follicles. They were divided into three groups according to different treatments: group A(DFR group, dominant follicle removed, n=97) ,in which the dominant follicle was removed by ultrasound-guided follicular aspiration on the day of the dominant follicle presented; group B(increasing GnRH-a dosage group, n=88) ,in which GnRH-a dosage was increased，patients received GnRH-a o.1mg/day(previous GnRH-a dosage was 0.05mg/day ); group C（control group , n=52）,in which patients received none of above treatments. Outcomes such as number of retrieved oocytes and MⅡoocytes, number of embryos suitable for embryo transfer, pregnancy rate and live birth rate per ET cycle，and so on, were compared among three groups. The difference of diameter between dominant follicle and subdominant follicles, the stimulated days, the dosage of GnRH-a, the total Gonadotropin (Gn) ampoules were also compared among three groups. Proportional differences of the main outcome measures were analyzed with χ2-test, Analysis of variance(ANOVA) was used to sample mean comparison. Differences were considered to be significant if P-value＜0.05. Results：1. Maternal baseline characteristics including Maternal age , duration of infertility， basal FSH level and LH level， BMI，and number of antral follicles on the day of stimulation started did not differ among the groups in a significant manner. The total dosage of GnRH-a in increasing GnRH-a dosage group was more than in DFR group and control group (13.94±1.71、11.82±2.50、11.27±2.38, respectively，P＜0.05) during ovarian stimulation. The total stimulated days （9.81±2.07 VS 9.2±1.29， P＜0.05） and the total Gn ampoules