测定混浊介质参数用MC仿真与逆运算加速算法的研究-生物医学工程专业论文.docxVIP

ABSTRACT The interactions of light and turbid media mainly can be divided into two types of processes, absorption and scattering. Many materials in nature are optically turbid where light scattering dominates the interaction, such as ceramic, milk, cell suspension, most of human tissues, etc. Determination of the optical parameters of turbid medium samples has wide range of applications in material research and clinical studies. Therefore, the development of efficient tools for accurate modeling of the interaction between light and turbid medium is critically important to determination of optical properties of turbid materials and establishment of the foundation for design of new instrument. As a result, study of new methods to determine the optical parameters of turbid media has attracted much attention in recent decades. Our research consists of the following parts to develop a fast method for inverse determination of optical parameters of a homogeneous turbid sample from the measured signals: The goal of this thesis research is to develop an inverse algorithm that can be combined with a new multi-parameters spectrophotometer employing a simple optical design for implantation in comparison to the integrating-sphere based complex design. In the new spectrophotometer design the solid angle range afforded by a light detector for measuring the diffuse transmittance or diffuse reflectance signals is generally three magnitudes smaller than the one measured with an integrating sphere. Consequently, it is very theoretically challenging to develop a method for rapid and accurate calculation of the light signals measured within small solid angle ranges for inverse determination of the optical parameters of a turbid medium sample using an iteration method. Furthermore, successful development of such method can lead to wide ranged applications. Computational cost is always one of factors which limit the application and accuracy of Monte Carlo simulation methods despite its a