暴发型流行性脑脊髓膜炎早期诊断及免疫治疗的探讨.docVIP

暴发型流行性脑脊髓膜炎早期诊断及免疫治疗的探讨 　　[摘要] 目的 对暴发型流行性脑脊髓膜炎的早期诊断和免疫治疗的效果进行探讨。方法 随机选取2013年1月―2014年1月入住该院进行治疗的60例暴发型流行性脑脊髓膜炎患儿作为研究对象，将其随机分为对照组和观察组，每组30例患儿，对照组患者进行常规治疗，观察组患儿在对照组的基础上进行免疫球蛋白联合甲基泼尼松龙静脉滴注。对两组患儿的神志转清时间、降温情况、血压恢复时间、休克纠正时间以及病死率进行观察。结果 两组患儿的昏迷、高热、血压下降、休克等症状均明显改善，观察组患儿的神志转清时间、血压恢复时间以及休克纠正时间均明显优于对照组（P0.05），观察组患儿的死亡率明显优于对照组（P0.05）。结论 加用免疫球蛋白联合甲基泼尼松龙静脉注射能够提高患儿的免疫力，有效提高免疫治疗效果。 　　[关键词] 暴发型流行性脑脊髓膜炎；免疫球蛋白；早期诊断；免疫治疗 　　[中图分类号] R515.2 [文献标识码] A [文章编号] 1674-0742（2015）06（c）-0043-02 　　[Abstract] Objective To discuss the effect of the early diagnosis and immunotherapy of fulminant epidemic cerebrospinal meningitis Methods 60 children with fulminant epidemic cerebrospinal meningitis who were admitted and treated in our hospital were selected as the research object and randomly divided into control group and observation group， 30 cases in each group. Patients in the control group underwent conventional treatment based on which those in the observation group underwent intravenous drip of immune globulin combined with methylprednisolone. The turn conscious time， cooling conditions， blood pressure recovery time， shock redress time， and mortality rate were compared between the two groups. Results Of the two groups， symptoms including coma， fever， drop in blood pressure， shock， etc were significantly improved， and in terms of turn conscious time， recovery time and shock redress time， the observation group were significantly better than that of control group （P0.05）； child mortality of the observation group was obviously better than that of the control group（P0.05）. Conclusion Intravenous drip of immune globulin combined with methylprednisolone based on the conventional treatment can improve childrens immunity thus effectively improve the effect of immunotherapy. 　　[Key words] Fulminant epidemic cerebrospinal meningitis； Immune globulin； Early diagnosis； Immunotherapy 　　暴发型流行性脑脊髓膜炎是一种死亡率较高的危重疾病，其发病骤急，病情恶化快，多发于儿童[1]。有关资料表明，早期诊断和免疫治疗是暴发型流行性脑脊髓膜炎降低死亡率的有效措施[2]。该研究随机选取2013年1月―2014年1月入住该院进行治疗的6