从氨苄西林钠生产废料中回收异辛酸钠的实验研究-化学工程专业论文.docxVIP

Dissertation Submitted to Hebei University of Technology for The Master Degree of Chemical Engineering EXPERIMENTAL STUDY ON THE RECOVERY OF SODIUM 2-ETHYLHEXANOATE FROM AMPICILLIN SODIUM PRODUCTION WASTE by Wu Nanxing Supervisor: Associate Prof. Wang Zhiying May 2015 摘 要 溶媒结晶法是氨苄西林钠等头孢类钠盐抗生素生产的常用方法。在以异辛酸钠为 成盐剂的溶媒结晶法生产过程中，产生了大量富含异辛酸盐的结晶母液。目前，国内 企业对结晶母液的回收工艺中仅包含溶媒的回收，对于溶媒回收后的废料通常采用填 埋法或焚烧法处理，既污染环境又造成巨大的浪费。因此，对氨苄西林钠生产废料中 的异辛酸盐进行分离回收，具有巨大的经济效益。 本文提出了从溶媒结晶法氨苄西林钠生产废料中回收异辛酸钠的工艺方法，并对 该工艺过程进行了系统的实验研究。 分别对回收工艺中的加酸酸化过程、减压精馏过程及异辛酸钠合成过程进行实验 研究。考察了酸种类和废料 pH 值对异辛酸粗品纯度的影响，确定了酸化过程所用的酸 与废料 pH 值；探讨了减压精馏过程塔顶压强和回流比对异辛酸纯度和收率的影响，确 定了精馏操作压力和回流比。考察了碱种类、反应温度、反应时间和搅拌速率对异辛 酸钠合成过程中异辛酸转化率和异辛酸钠纯度的影响，得到了较优反应条件，所得异 辛酸钠纯度可达 97.66%。 对工艺分离回收前后的废料进行了环境指标分析，结果发现，经本工艺处理后排 放的废料其 COD 总量下降约 11.33%，氨氮总量下降约 8.18%。对废料分离回收工艺进 行粗略经济效益分析，年产 200 吨氨苄西林钠时，预计每年通过本工艺回收处理废料， 可获利约 310 万元。 关键词：氨苄西林钠；异辛酸；异辛酸钠；回收；纯度；收率 I ABSTRACT Solvent crystallization is a common method in the production of cephalosporin antibiotics like ampicillin sodium. There is a large number of crystallizing mother liquid includes numerous isooctoate salt generated during the solvent crystallization production process which use sodium 2-ethylhexanoate as salt forming agents. Currently, the domestic enterprises only recycle the solvent, but the waste after solvent recovery usually disposed by landfill or incineration on the recovery process of crystallization mother liquor, it brings to not only environment pollution and also huge wastefulness. Therefore, it will be have great benefits of economic and environmental to separate and recycle the isooctoate salt from the waste of ampicillin sodium production process. In this paper, a method about recycling sodium 2-ethylhexanoate from the waste after solvent recovery of ampicillin sodium production process is proposed, and also study this process from experiment systematically. The experiment research focus on plus acid process, vacuum distillation process, and sodium 2-ethylhexanoate synthesis process