溃结宁膏穴位贴敷治疗脾肾阳虚型溃疡性结肠炎临床的研究.docVIP

溃结宁膏穴位贴敷治疗脾肾阳虚型溃疡性结肠炎临床的研究 　　摘要：目的 观察溃结宁膏穴位贴敷治疗脾肾阳虚型溃疡性结肠炎（UC）患者的临床疗效及对血清干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）水平的影响。方法 将60例UC患者分为治疗组、对照组和联合治疗组，每组20例，分别予溃结宁膏穴位贴敷加服安慰剂、口服柳氮磺胺吡啶加安慰贴、溃结宁膏穴位贴敷加服柳氮磺胺吡啶治疗，60 d后观察3组临床综合疗效、黏膜病变疗效、黏膜病理疗效及治疗前后血清IFN-γ、IL-4的变化。结果 3组临床综合疗效、黏膜病变及黏膜病理疗效相当，差异无统计学意义（P0.05）。3组治疗后IFN-γ水平明显降低，IL-4水平明显增高（P0.01）；治疗组、联合治疗组与对照组比较，差异有统计学意义（P0.05，P0.01）。结论 溃结宁膏穴位贴敷联合柳氮磺胺吡啶治疗脾肾阳虚型UC，可调节体内免疫细胞因子水平，具有较好的临床疗效。 　　关键词：溃结宁膏；穴位贴敷；溃疡性结肠炎；脾肾阳虚；干扰素-γ；白细胞介素-4 　　DOI：10.3969/j.issn.1005-5304.2013.07.005 　　中图分类号：R259.746.2；R245.99 文献标识码：A 文章编号：1005-5304（2013）07-0010-03 　　Clinical Research of Kuijiening Paste Acupoint Application in Treating Ulcerative Colitis of Spleen-kidney Yang Deficiency Type GUO Wei-jun1， ZHU Ying2， ZHAO Xi1 （1.Liuyang City Hospital of TCM， Changsha 410300， China；2.The Second Affiliated Hospital of Hunan University of TCM， Changsha 410005， China） 　　Abstract：Objective To observe the clinical efficacy of Kuijiening Paste acupoint application on ulcerative colitis （UC） patients of spleen-kidney Yang deficiency type， and its effect on serum levels of IFN-γ and IL-4. Methods Sixty UC patients were divided into treatment group， control group and combined treatment group， 20 cases in each group， and were given Kuijiening Paste acupoint application plus placebo， oral sulfasalazine plus comfort paste and Kuijiening Paste acupoint application plus sulfasalazine respectively for 60 days. The clinical efficacy， mucosal lesions efficacy， mucosal pathology efficacy， changes of serum IFN-γ and IL-4 were observed after treatment. Results There was no significant difference in clinical efficacy， mucosal lesions efficacy and mucosal pathology efficacy among the three groups （P0.05）. After treatment， IFN-γ levels of the three groups significantly reduced， and IL-4 levels significantly increased （P0.01）. The difference between the treatment group and the control group was significant （P0.05）. The difference between the combined treatment group and the control group was signif