两种联合方案治疗2型糖尿病的成本效果分析.docVIP

两种联合方案治疗2型糖尿病的成本-效果分析 葛震坤 (安徽省含山县人民医院内三科 238100) 】目的：比较两种联合方案治疗2型糖尿病的成木效果。方法: 2型糖尿病62例，随机分为A组(格列美脲联合二甲双胍，33例)、B组(格列美 脲联合毗格列酮，29例)，观察空腹血糖、餐后2小时血糖的变化，用药物经济 学中的成木效果分析法对两种治疗方案进行评价。结果：血糖控制有效率、低血 糖发生率两组无统计学差异(Pgt;0.05), A组成木(1659.31元)低于B组(2036.45 元)，差异有统计学意义(Plt;0.05,以成木较低的A组为参照，增量成木效果比B 组为269.39，敏感度分析示两组药物降价10%后增量成木效果比B组为242.45。 结论：格列美脲联合二甲双胍方案治疗2型糖尿病的成木效果优于格列美脲联合 毗咯列酮方案。 关键词】2型糖尿病格列美脲二甲双胍毗格列酮成木-效果 分析 】R587.1 】A 】2095-1752 (2014) 18-0065-02 Cost - effectiveness analysis of two joint programs in the treatment of type 2 diabetes Ge Zhen-kun. Department of third Internal Medicine, the Peoples Hospital of Hanshan County, Hanshan 238100, Anhui Abstract】 Objective To compare the cost-effectiveness of two joint programs in the treatment of type 2 diabetes. Methods 62 cases with type 2 diabetes were randomly divided into group A(glimepiride combined metformin ,33 cases｝、group B(glimepiride combined pioglitazone,29 cases),the change of fasting blood glucose、2-hour postprandial blood glucose were observed , with the pharmacoeconomics cost-effectiveness analysis in the two treatment programs were evaluated. Results The effeciency of glycemic control、the incidence of hypoglycemia was no significant difference between two groups (Pgt; 0.05),Costs in group A(1659.31 Yuan) was less than in group B (2036.45 Yuan), with significant difference(P lt; 0.05), with a lower cost of group A as a reference, the incremental cost- effectiveness ratio was 269.39 in group B,the sensitivity analysis shows,the incremental cost-effectiveness ratio after the two groups of drug prices 10% was 242.45 in group B . Conclusion glimepiride combined metformin in the treatment of type 2 diabetes was better than glimepiride combined pioglitazone in cost-effectiveness. Key words] type 2 diabetes glimepiride metformin pioglitazone cost - effectiveness analysis 2型糖尿病是严重威胁人类健康的慢性疾病，近年我国2型糖尿病患病 率呈上升趋势[1】，给患者和社会造成了巨大的经济负担。为选择经济、有效的 治疗方法，本文运用成本-效果分析的方法对62例分组治疗的2型糖尿病患者进 行了研宄，现将结果报告如下。 1资料与方法 1.1 一般资料我院自2011年4