清肺散结丸辅助经皮穿刺氩氦刀靶向冷冻治疗老年晚期非小细胞肺癌临床的研究.docVIP

清肺散结丸辅助经皮穿刺氩氦刀靶向冷冻治疗老年晚期非小细胞肺癌临床的研究 　　摘要：目的 ?^察清肺散结丸辅助经皮穿刺氩氦刀靶向冷冻治疗老年晚期非小细胞肺癌（NSCLC）的疗效及其对免疫功能的影响。方法 采用抽签法将94例老年晚期NSCLC患者分为观察组与对照组各47例。2组均采用经皮穿刺氩氦刀靶向冷冻治疗，手术后复查CT，观察病灶情况。观察组并予清肺散结丸，每次1瓶，每日2次，口服，共治疗3个月。评价2组近期疗效，观察2组治疗前后IgG、IgA、CD3+、CD4+、CD8+水平及术后并发症。观察2组1、2、3年生存率。结果 观察组和对照组分别脱落2、3例。观察组总有效率为84.4%（38/45），对照组为65.9%（29/44），2组比较差异有统计学意义（P0.05）。与本组治疗前比较，2组治疗后IgG、IgA、CD3+、CD4+、CD8+水平明显升高（P0.05），治疗组治疗后IgG、IgA、CD3+、CD4+、CD8+水平高于对照组（P0.05）。治疗后，观察组咳嗽加重、术后疼痛、痰中带血、发热及恶心呕吐的发生率均低于对照组（P0.05）。观察组1、2、3年生存率分别为91.1%、75.6%、64.4%，对照组分别为79.5%、63.6%、52.3%，2组相同时点比较差异有统计学意义（P0.05）。结论 清肺散结丸辅助经皮穿刺氩氦刀靶向冷冻治疗老年晚期NSCLC疗效较好，可改善患者免疫功能，提高生存率。 　　关键词：清肺散结丸；氩氦刀靶向冷冻治疗；老年；晚期；非小细胞肺癌 　　DOI：10.3969/j.issn.1005-5304.2017.11.007 　　中图分类号：R273.42 文献标识码：A 文章编号：1005-5304（2017）11-0026-04 　　Abstract： Objective To study the clinical efficacy of Qingfei Sanjie Pills combined with targeted cryoablation therapy on elderly patients with advanced non-small cell lung cancer （NSCLC） and its influence on the levels of immune function in patients. Methods Totally 94 elderly patients with NSCLC were divided into observation group and control group， with 47 cases in each group. Both groups were given targeted cryoablation therapy and under CT review after surgery to observe lesions condition. Observation group was given Qingfei Sanjie Pills， once a bottle， twice a day， orally， for three months. Recent efficacy of the two groups were evaluated. The levels of IgG， IgA， CD3+， CD4+， CD8+， and complications in the two groups were detected. The survival rate of 1 year， 2 years and 3 years in the two groups were observed. Results Two cases in the observation group and three cases in the control group were invalid. The total effective rate was 84.4% （38/45） in observation group and 65.9% （29/44） in the control group， with statistical significance （P 　　Key words： Qingfei Sanjie Pills； targeted cryoablation therapy； elderly； advanced； non small cell lung cancer 　　通讯作者：汪海燕，E-mail：wanghaiyan2001@163.com 　　非小细胞肺癌（non-small cell lung