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PAGE 458 ISSN1000-3061 CN11-1998/Q Chin J Biotech March 25, 2009 Vol.25 No.3 眉题 PAGE 2 Journals.im.ac.cn Journals.im.ac.cn 生物工程学报 Chin J Biotech 2009, March 25; 25(3): 457-463 journals.im.ac.cn Chinese Journal of Biotechnology ISSN 1000-3061 cjb@im.ac.cn ? 2009 Institute of Microbiology, CAS CSM, All rights reserved 生物技术与方法 生物技术与方法 Received: October 24, 2008; Accepted: December 3