奎硫平与氟哌啶醇治疗精神分裂症对照研究..docVIP

奎硫平与氟哌啶醇治疗精神分裂症对照研究 ：陶建青刘佳斌梁亚志李伟生冯昌生 】目的评价奎硫平与氟哌啶醇治疗精神分裂症 的疗效及安全性。方法将59例精神分裂症患者随机分为两 组，研究组30例，口服奎硫平治疗；对照组29例，口服氟 派啶醇治疗。观察8w。于治疗前及治疗第2 w、4w、8w末采 用潘氏量表评定临床疗效，副反应量表评定不良反应。结果 治疗8w末研究组有效率为90%，对照组为％。潘氏量表评分 治疗2w末起两组总分、阳性症状分及研究组一般精神病理 分，4w末起研究组阴性症状分及对照组一般精神病理分均较 治疗前有显著下降；8 w末对照组阴性症状分虽较治疗前有 所下降，但无显著性差异；研究组治疗2w末一般精神病理 分、4w末总分及阴性症状分均较对照组下降显著，阳性症状 分各时点与对照组比较均无显著性差异。治疗8 w末副反应 量表评分研究组显著低于对照组。结论奎硫平治疗精神分裂 症的疗效优于氟哌啶醇，不良反应发生率低，且程度较轻， 安全性高，依从性好。 关键词】精神分裂症；奎硫平；氟哌啶醇；疗效 Acontrolstudyofq uetiapinevs. halope ridolinthetreatmen tofschizophrenia Abstract ] Objective Toevaluatetheeffi cacyandsafetyofque tiapinevs. haloperi dolinthetreatmento fschizophrenia. Met hods 59schizophren icswererandomlyass ignedintoresearchg rouptakingorallyqu etiapineandcontrol groupdoinghaloperi dolfor8weeks. Clini caleffectswereasse ssedwiththePositiv eandNegativeSyndro meScaleandadversee ffectswiththeTreat mentEmergentSympto mScaleatbaselinean dattheendofthe2nd ， 4th ， 6thand8thweekt reatment. Results A ttheendofthe8thwee k ， effectiverateswe rerespectively90%i ntheresearchand%in thecontrolgroup. Ac cordingtothePANSS ， thetotalandpositiv esymptomsscoresofb othgroupsandgenera lpsychopathologica lscoreoftheresearc hsincetheendofthe2 ndweek ， andnegative symptomsscoreofthe researchandgeneral psychopathological scoreofthecontrols incetheendofthe4th 1oweredmoresignifi totalscoreandnegativesymptomsscoreslowcantlycomparedwith pretreatment ； atthe endofthe8thweek, to talscoreandnegativ esymptomsscoreslow eredcomparedwithpr withpretreatmentbu tsignificantinthec hopathologicalscor eekandtotalandnegaattheendofthe4thlo eredcomparedwithpr withpretreatmentbu tsignificantinthec hopathologicalscor eekandtotalandnega attheendofthe4thlo ntlyintheresearcht tdifferenceswereno ontrol ； generalspyc eattheendofthe2ndw tivesymptomsscores weredmoresignifica haninthecontrolgro up tpositivesymptomss oups. Attheendofthe rewassignificantly thaninthecontrolgr tiapineismoreefficncidenceofadverseeyandbettercompliancoresbetweenthe2gr8thw