银杏达莫注射液联合雷米普利对2型糖尿病肾病临床的的疗效观察.docVIP

银杏达莫注射液联合雷米普利对2型糖尿病肾病临床的的疗效观察 　　【中图分类号】R587.2【文献标识码】B【文章编号】1672－3783(2011)08－0445－01 　　【摘要】目的：通过银杏达莫注射液与雷米普利联合治疗糖尿病肾病前后尿微量白蛋白/肌酐（UAlb/Cre）水平的变化，观察银杏达莫注射液治疗糖尿病肾病的临床疗效。方法： 将75例2型糖尿病肾病受试者，随机分为银杏达莫注射液与雷米普利联合治疗组（治疗组）和单用雷米普利治疗（ACEI组）。分别应用雷米普利（2.5mg~5mg/d）加用银杏达莫注射液20ml加入250ml生理盐水中静脉滴注治疗及单用雷米普利每日2.5mg~5mg 治疗4周。观察治疗前后尿微量白蛋白/肌酐（UAlb/Cre）水平的变化。结果 ：1. 治疗组及ACEI组患者治疗后UAlb/Cre等均较治疗前有明显下降（39.37±2.46 ug/mg vs 69.85±5.04 ug/mg ; P ＜0.01；46.88±3.07ug/mg vs 71.79±5.64 ug/mg ; P ＜0.01）。2 . 治疗组UAlb/Cre的改善明显优于对照组(39.37±2.46 ug/mg vs 46.88±3.07ug/mg ; p＜0.05)。结论 : 银杏达莫注射液联合雷米普利治疗可明显降低UAlb/Cre，对肾功能的改善优于单用雷米普利治疗。 　　【关键词】糖尿病肾病 ; 尿微量白蛋白 ; 　　Ginkgo biloba extract and dipyridamole injection combined with Ramipril in type 2 diabetic nephropathy Clinical observation 　　 WU Yan , YU He-lin , LIU Yang , JIANG Li , CHEN Cheng , 　　【Abstract】 Objective By Ginkgo biloba extract and dipyridamole injection before and after ramipril treatment of diabetic nephropathy urinary albumin / creatinine (UAlb / Cre) levels in observed ginkgo biloba extract and dipyridamole injection in the treatment of diabetic nephropathy. Methods 75 patients with type 2 diabetic nephropathy subjects were randomly divided into two gingko injection combined with ramipril treatment group (treatment group) and single therapy with ramipril (ACEI group). Were ramipril (2.5mg ~ 5mg/d) plus added gingko injection 20ml and 250ml normal saline intravenous treatment and a single 2.5mg ~ 5mg daily with ramipril treatment for 4 weeks. Of treatment, urinary albumin / creatinine (UAlb / Cre) level changes. Results 1. Treatment group and ACEI group patients after treatment UAlb / Cre were significantly decreased than before (39.37±2.46 ug/mg vs 69.85±5.04 ug/mg ;P ＜0.01；46.88±3.07ug/mg vs 71.79±5.64 ug/mg ;P ＜0.01). 2. The treatment group UAlb / Cre (39.37±2.46 ug/mg vs 46.88±3.07ug/mg ; p 0.05) improvement than the control group . Conclusion Ginkgo biloba extract and dipyridamole injection combined with ramipril treatment can significantl