c-Met抑制剂PHA-665752联合贝伐单抗或西妥昔单抗对结肠癌移植瘤生长的抑制作用与机制.pdf

英文摘要 TheInhibitionInfluencec．MetinhibitorsPHA一665752 0rCetuximabHaveOnThe CombinedWithBevacizumab Cancer TumorAndThe GrowthOfColon Xenograft Mechanism ABSTRACT cancerisacommon tumorto Background：Colorectal malignant thehuman incidencehasa tract，whose rapidlyrising digestive inour additionto and tendency country．In surgery，radiation hasbecomethefourthortreatment chemotherapy,targetedtherapy maj inthe and ofthedisease．But of processdrug restrictsthe drug·resistantproblem complicationsappear，especially ofthe the hada”bottleneck”． developmentdrugs，makingapplication Aswe isamolecularnetwork thereisa know，Tumor disease，and or directindirecteffectoneachotherbetweendifferent signaling oneofthe isblockedtheactivationofother pathways．If pathways be inhibitionof waysmaycaused．Therefore，the multipletargets，that is，the of hasbecomearesearch jointapplicationtargeteddrugs hotspot． TheointofVEGFandEGFR PFS makes