TGFα、VEGF与MV在银屑病患者皮损中的表达及相关性分析.docVIP

TGF-a、VEGF与MVD在银屑病患者皮损中的表达及相关性分析 李岳军(湖南省益阳市屮心医院湖南益阳413000) 屮图分类号】R758.2 】A 】1672-5085 (2012) 19-0059-03 】R的探讨转化生长因子alpha;(TGF-alpha;)及血管内皮生长因子(VEGF) 在银屑病患者皮损血管生成机制屮的作用。方法采用SP免疫组化法检测寻常型 银屑病患者皮损处TGF-alpha;、VEGF及微血管密度(MVD)的表达情况，并以正 常人皮肤作对照。结果银屑病患者皮损处GF-alpha;、VEGF的表达及MVD值 显著高于正常对照组(Plt;0.01);银屑病患者皮损屮的TGF-alpha;、VEGF表达与 MVD 呈正相关(r=0.672, r=0.735,均 Plt;0.01),TGF-alpha;与 VEGF 的表达也呈正 相关(r=0.821, Plt;0.01)o结论银屑病患者皮损屮TGF-alpha;、VEGF及MVD 的表达水平均增高，表明TGF-alpha;及VEGF可能引起银屑病患者皮损处血管增 生，三者在银屑病皮损的形成发展过程屮可能发挥协同促进调节作用。 关键词】银屑病TGF-alpha; VEGF MVD Study on the correlation between expression of TGF-alpha;, VEGF and MVD in the psoriatic lesions Li yue-jun (Yiyang Central Hospital,丫iyang, Hunan ,413000,China) [Abstract] Objective To explore the effect of TGF-alpha; and VEGF in the mechanism of the angiogenesis of psoriasis vulgaris.Methods: SP immunohistochemistry was used to detect the the expression of TGF-alpha;,VEGF and MVD from samples of psoriasis vulgaris tissue. Meanwhile,those factors were detected in normal skin tissue as control..Results: The expression of TGF-alpha;,VEGF and MVD in psoriasis vulgaris tissue group were signifcantly higher than those in the normal group (Plt;0.05).The expression of TGF-alpha;,VEGF were positively correlated with MVD levels in psoriasis vulgaris tissue group(r=0.672, r=0.735, all Plt;0.01), the expression of TGF-alpha; was also positively correlated with VEGF(r=0.821, Plt;O.Ol). Conclusion： The expression are increased of. TGF-alpha;,VEGF and MVD inpsoriasis vulgaris lesions, they may play positive roles in regulating and facilitating synergy in the lesion specimens of psoriasis. Keywords】 psoriasis TGF-alpha; VEGF MVD 银屑病(psoriasis, PS)是一种常见的复发性、慢性炎症性皮肤病，其组织 病理特征是角质形成细胞过度增生，炎症细胞浸润，新生血管形成。其患者皮损 微血管异常是体内促血管新生因子和抗血管新生因子不平衡的结果。体外实验发 现转化生长因子(TGF-alPha;＞可以诱导角质形成细胞产生血管内皮生长因子 (VEGF),二者可能在血管增生中起协同作用［1］。我们通过检测银屑病皮损中 TGF-alpha;、VEGF、CD34 表达，旨在探讨 TGF-alpha;、VEGF 与微血管密度(MVD) 相互关系及其在银屑病发生中的作用。 1资料与方法 1.1 一般资料2010年1月?2011年6月我院皮肤科门诊的银屑病患 者60例，其中男48例，女12例