SsT引导下125I粒子植入联合全身化疗治疗晚期非小细胞肺癌的临床观察.docVIP

Ss CT引导下1251粒子植入联合全身化疗治疗晚期非小细胞肺癌的临床观察 林辉苏香花肖建宏彭锦芸(福建医科大学附属闽东医院呼吸科福建 福安 355000) 】FI的探讨观察CT引导丁 1251放射性粒子植入联合吉西他滨、顺钥(GP 方案)化疗治疗晚期非小细胞肺癌(NSCLC)的临床疗效和安全性。方法66例III b?IV期NSCLC患者分为(实验组)30例：采用CT引导K粒子植入联合全身化疗和 (对照组)36例：化疗组，两组化疗方案均为吉西他滨联合顺铂，术后I、3、6个 月分别进行随访做CT检查，观察各有效率和毒副反应。结果实验组和对照组 的总体有效率分别为80.00%和50.00%,两组间有显著的统计学差异(plt;0.05), 所有的不良反应及并发症可控，实验组有较高的血痰和胸痛、气胸发生率 (plt;0.05),两组在发热、骨髓抑制方面无差异((pgt;0.05?，所有患者末出现放 射损伤症状、未发现粒子迁移。结论放射性粒子1251植入联合化疗治疗晚期非 小细胞肺癌有较好的近期临床疗效和可以控制的毒副不良反应，是晚期非小细胞 肺癌安全、有效的治疗手段。 关键词】非小细胞肺癌放射性粒子1251化疗近距离放疗 屮图分类号】R730.5 】A 】2095-1752 (2013) 13-0118-03 Curative Effect of CT-guided 1251 seeds implantation combined with chemotherapy for Advanced Non-small cell Lung Cancer Lin Hui Su Xiang-hua, Xiao Jian-hong, Peng Jin-yun Respiratory department of Min Dong hospital of Fu Jian Medical university, Fu An FuJian, China, 355000 Abstract】 Objective To explore the curative effect and safety of CT-guided radioactive 1251 seeds implantation combination with GP regimen(GEM+DDP) chemotherapy for advanced non-small cell lung cancer (NSCLC). Methods The 66 cases NSCLC patients (Illb?IVstage)were randomly divided into two groups: CT-guided seeds implantation combined with chemotherapy group(experimental group, n=30) and pure chemotherapy group (control group, n=36), two groups were both accepted GP regimen(GEM+DDP) chemotherapy. And they were followed up by CT examination after I, 3 ,6 months. The efficacy and adverse effects of both groups were compared. Results In the CT-guided seeds implantation combined with chemotherapy group and the pure chemotherapy group, the response rate (CR plus PR) was 80.0% and 50.0%, respectively. There were significant differences in two groups (plt;0.05). All the adverse reactions and complications were controllable. The experimental group had higher bloody sputum, chest pain and pneumothorax incidence(plt;0.05), but, there were no significant differences in fever and bone marrow suppression. There were no radiation injury symptoms and pa