PL1在非肌层浸润性膀胱癌的表达及其对术后膀胱灌注治疗的影响分析.docVIP

PD-L1在非肌层浸润性膀胱癌的表达及其对术后膀胱灌注治疗的影响分析 四川省郫县人民医院外四科611730 目的探讨程序性死亡配体1 (Programmed death ligand 1, PD-L1)在 非肌层浸润性膀胱癌组织屮的表达情况及对术后采用膀胱灌注治疗效果的影响 作用。方法选取本院泌尿外科收治的60例术后病理检查确诊为非肌层浸润性膀 胱癌患者的病理组织标本(膀胱癌组)，病理科既往病理检查收集的20例正常膀 胱组织标本(正常组)，分析PD-L1表达与患者的病理临床特征的关系及对患者 灌注治疗预后效果的影响作用。结果PD-L1在膀胱癌组织屮的阳性表达率 (60.00%)显著高于正常组(0%),差异具有统计学意义(Plt;0.05)。PD-L1在 膀胱癌组织屮的阳性表达率患者肿瘤病理分期关系密切(Plt;0.05)o PD-L1阳性 表达的膀胱癌患者的3年无瘤生存率(75%)显著低于PD-L1阴性表达的膀胱癌 患者的3年无瘤生存率(95.83%) (Plt;0.05)。PD-L1阳性表达的膀胱癌患者的 3年生存率(86.11%)低于PD-L1阴性表达的膀胱癌患者的3年生存率(95.83%), 但差异无统计学意义(Pgt;0.05)。结论PD-L1在非肌层浸润性膀胱癌组织屮呈 高表达，并且与患者的肿瘤病理分期具有一定的关系，PD-L1阴性表达患者3年 无瘤生存率高于阳性患者。 关键词：程序性死亡配体-1;非肌层浸润膀胱癌；膀胱；灌注治疗；预后 The expression of PD-L1 in non muscle invasive bladder cancer and its effect on postoperative bladder perfusion Chen Liang Wu Bo Chen Guo (The four families of the Pixian peoples Hospital of Sichuan Province, 611730) Abstract】Objective To investigate the expression of-1(PD-Ll)in non muscle invasive bladder cancer tissues and its effect on bladder perfusion. Methods Selected the hospital of 60 cases of postoperative pathological examination confirmed the diagnosis of non muscle invasive bladder cancer tissue( bladder cancer group), Department of Pathology； previous pathological examination collected 20 cases of normal bladder tissue specimens (normal group)，To analyze the relationship between PD-L1 expression and patient age，sex and the pathologic clinical features and influence of perfusion in patients with the effect of the treatment of prognosis.Results PD-L1 expression rate (60.00%) in bladder cancer tissues was significantly higher than normal group (0%) and the difference was statistically significant (Plt;0.05) .PD-L1 expression in patients with bladder carcinoma tumor staging closely related (Plt;0.05) .3-year disease-free survival of patients with bladder cancer, the positive expression of PD-Ll(75%)was significantly lower than the negative expression of PD-L1 bladder cancer 3-year survival rate (95.83%) (P lt;0.05) .PD-L1 3-year sur