PPS病人血清与前列腺按摩液uZnS和MA检测及意义　.docVIP

CPPS病人血清与前列腺按摩液CuZnSOD和MDA检测及意义 】目的通过对慢性骨盆疼痛综合征(cpps)病人 和健康男性的血清和前列腺按摩液(EPS)中铜锌超氧化物歧 化酶(CuZn?SOD)活力、丙二醛(MDA)含量测定，探讨其在 CPPS诊断、治疗中的意义。方法将门诊确诊的40例CPPS 病人分为炎性组和非炎性组，以20例健康男性为对照组， 采用黄嘌呤氧化酶法测定CuZn?SOD活力，硫代巴比妥酸 (TBA )法测定MDA含量。结果各组血清中CuZ n?SOD活力比 较差异无显著性(P〉)。炎性组及非炎性组血清中MDA含量 明显高于对照组(F=，q=、，P)。炎性组EPS中CuZn?SO D 活力明显低于非炎性组及对照组(F=，q=、，P)。炎性组 EPS中MDA含量明显高于非炎性组及对照组(F=，q=、，P)。 结论炎性C PPS病人前列腺氧化应激水平高于健康男性，非 炎性CPPS病人前列腺氧化应激水平与健康男性无明显差别; 血清及EP S中C uZn?SOD、MD A水平可作为CPP S诊断和判 断疗效的有意义的辅助指标，SOD制剂在CPPS的治疗中可 能具有重要作用。 关键词】慢性骨盆疼痛综合征;铜锌超氧化物歧化酶; 丙二醛 [ABS TRAC T]Objec tiv eTodeter mi netheleve 1 sofCuZn?S0 DandMDAinse rumandEPSin patientswi t hchronicp el vicpains ynd rome(CP PS)a ndexpl oreth eirsi gnific ance inthedi agn osisandt re atmentoft h isconditio n. MethodsFo rtyoutpatie ntsconfirm e dashaving CP PSweredi vid edintoi nfla mmator ygrou pandn on?inf lamm atorygr oup and20hea It hyserveda s thecontrol . XanthineOx idasemethod wasapplied t odetermin et heconten tof CuZn?S0 Dand TBAmet hodto deter mineth elev elofThe lev elsofCuZ n?SODinseru m amongtheth reegroupswe renotsignif icantlydif f erent(P).T heseruml eve IsofMDA inCP PSpati entsw eresi gnific anti yhigher tha nthatoft he control (F =;q=， :P).Th evigourofCu Zn?SODinthe EPSofthein f lammatory gr oupwasma rke dlylowe rtha nthati nthen on?in flamma tory groupan dth econtrol (F =; q=, : P). T heMDAinEPS oftheinflam matorygroup wasdramati c allyhighe rt ha.ntha.ti nth enon?in flam mat or y andth econt rol (F=;q=, :P).Con clu sionTheo xi dativestr e ssofEPSpat ientswithin flammatoryC PPSisstron g erthantha to ftheheal thy adults, whil ethere isnos ignif icantd iffe ?renceo fth eoxidati ve stressbet w eenpatient swiththenon ?inflammato ryCPPSandt h ehealthyo un gman. Mea sur ementso fthe levels ofCuZ n?SOD andMDA，bot hinseru man dEPS, can se rveasvalu a bleparamet ersinthedia gnosisandas sessmentof t hetherapy of CPPS. [KEY WORDS] Chron icpel vicpai nsyn drome;C uZn ?superox id edismutas e :Malondial dehyde 慢性前列腺炎是成年男性男科门诊最常见的疾病之一 其诱