普鲁卡因青霉素治疗二期梅毒临床效果及预后剖析.docVIP

普鲁卡因青霉素治疗二期梅毒临床效果及预后剖析 　　【摘要】目的：探讨普鲁卡因青霉素治疗二期梅毒临床效果，并观察和分析其及预后，为临床治疗提供依据。方法：选择本院2011年1月至2013年12月二期梅毒患者110例，随机分为对照组和观察组，对照组应用阿奇霉素治疗，观察组应用普鲁卡因青霉素治疗。观察各组患者治疗的临床治疗效果、皮疹消失时间，治疗后两年对患者进行随访，检测6、12、24个月的RPR转阴率和TRUST滴度。结果：观察组总有效为9818%（54/55），高于对照组9091% （50/55），差异有统计学意义（P005）；观察组皮疹消失时间为（1039±106）d，低于对照组（1350±117）d，差异有统计学意义（P005）；观察组第6个月RPR转阴率和TRUST滴度分别为3091%（17/55）和153±054，对照组为2182% （12/55）和（187±062），差异具有统计学意义（P005）。结论：普鲁卡因青霉素和阿奇霉素治疗二期梅毒临床效果均较好，普鲁卡因青霉素更具优势，值得临床推广应用。 　　【关键词】普鲁卡因青霉素；二期梅毒；临床效果；预后 　　Clinical effect and prognosis of procaine penicillin in treating 2-phase syphilis patientsLI Hongfang1， CHEN Wenbo2. 1. Dermatology Department， Tonglu Branch of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine， （Tonglu County First People’s Hospital）， Hangzhou 311500， China； 2. Department of Gynaecology， Ningbo Medical Center Lihuili Hospital， Ningbo 315040， China 　　【Abstract】Objectives： To explore the clinical effect of procaine penicillin treatment for 2-phase syphilis patients， and analyze its prognosis， so as to provide basis for clinical treatment. Methods： 110 2-phase syphilis patients in our hospital from January 2011 to December 2013 were selected and randomly divided into the control group and the observation group. The control group received azithromycin for treatment， and the observation group was given procaine penicillin for treatment. The clinical therapeutic effect and time for rash to disappear were observed. The RPR negative conversion ratio and the TRUST degree were detected 6， 12 and 24 months after the treatment. Results：The total effective rate of the observation group was 98.18% （54/55）， higher than the control group of 9091% （50/55）， with statistically significant difference （P005）. The time for rash to disappear in the observation group was （1039±1.06） d， shorter than the control group of （13.50 ±1.17） d， with statistically significant difference （P005）. The RPR negative conversion ratio and the TRUST drops degree of the observa